| 2022-10-04 19:00:56October 4, 2022 | Dunnellon  | 38 - 6 | Hernando Leopards | 2022 | N/A |
| 2022-10-04 19:00:38October 4, 2022 | Nease  | 31 - 51 | Sandalwood Saints | 2022 | N/A |
| 2022-10-04 19:00:22October 4, 2022 | Titusville  | 40 - 0 | Space Coast Vipers | 2022 | N/A |
| 2022-10-04 19:00:11October 4, 2022 | Palatka Panthers | 26 - 21 |  Tocoi Creek | 2022 | N/A |
| 2022-10-04 19:00:07October 4, 2022 | Tavares  | 20 - 46 |  Leesburg | 2022 | N/A |
| 2022-10-04 18:00:42October 4, 2022 | Mount Dora  | 45 - 36 | Umatilla Bulldogs | 2022 | N/A |
| 2022-10-04 16:30:06October 4, 2022 | Faith Christian Academy Lions | 22 - 6 | Bell Creek Academy Panthers | 2022 | N/A |
| 2022-10-03 19:00:54October 3, 2022 | Ocala Christian Crusaders | 46 - 44 | Duval Charter School Panthers | 2022 | N/A |
| 2022-10-03 19:00:53October 3, 2022 | Williston Red Devils | 42 - 19 | Newberry Panthers | 2022 | N/A |
| 2022-10-03 19:00:51October 3, 2022 | Sarasota Christian Blazers | 42 - 12 | Academy At The Lakes Wildcats | 2022 | N/A |
| 2022-10-03 19:00:51October 3, 2022 | Eau Gallie  | 13 - 14 |  Merritt Island | 2022 | N/A |
| 2022-10-03 19:00:50October 3, 2022 | Eastland Christian Hurricanes | 18 - 13 | Calvary Chapel Eagles | 2022 | N/A |
| 2022-10-03 19:00:49October 3, 2022 | The First Academy Royals | 7 - 31 | Orlando Christian Prep Warriors | 2022 | N/A |
| 2022-10-03 19:00:43October 3, 2022 | Keystone Heights Indians | 0 - 38 |  Bradford Tornadoes | 2022 | N/A |
| 2022-10-03 19:00:32October 3, 2022 | St. Johns Country Day Spartans | 28 - 37 | FSDB Dragons | 2022 | N/A |
| 2022-10-03 19:00:28October 3, 2022 | Shorecrest Prep Chargers | 59 - 0 | Real Life Christian Raptors | 2022 | N/A |
| 2022-10-03 19:00:27October 3, 2022 | American Collegiate Academy Rough Riders | FORFEIT - WIN | Ambassadors Christian Academy Stallions | 2022 | N/A |
| 2022-10-03 19:00:24October 3, 2022 | North Marion  | 6 - 14 |  Eastside | 2022 | N/A |
| 2022-10-03 19:00:20October 3, 2022 | Bronson Eagles | 14 - 43 | Oak Hall Eagles | 2022 | N/A |
| 2022-10-03 19:00:18October 3, 2022 | Satellite  | 3 - 7 | Bayside Bears | 2022 | N/A |
| 2022-10-03 19:00:16October 3, 2022 | Middleburg  | 44 - 6 |  Ridgeview | 2022 | N/A |
| 2022-10-03 19:00:10October 3, 2022 | Ponte Vedra  | 17 - 20 |  Flagler Palm Coast | 2022 | N/A |
| 2022-10-03 19:00:07October 3, 2022 | Matanzas  | 7 - 42 |  St. Augustine | 2022 | N/A |
| 2022-10-03 19:00:02October 3, 2022 | TDH Christian Academy Eagles | 35 - 0 | Impact Christian Academy Lions | 2022 | N/A |
| 2022-10-03 18:00:58October 3, 2022 | Seven Rivers Christian Warriors | 27 - 40 | Bell Bulldogs | 2022 | N/A |
| 2022-10-03 18:00:31October 3, 2022 | Melbourne Central Catholic Hustlers | 7 - 54 | Father Lopez Green Wave | 2022 | N/A |
| 2022-10-03 17:30:55October 3, 2022 | Trinity Catholic Celtics  | 56 - 0 | St. Joseph Academy Flashes | 2022 | N/A |
| 2022-10-03 17:00:23October 3, 2022 | P.K. Yonge Blue Wave | 12 - 13 | Mount Dora Christian Bulldogs | 2022 | N/A |
| 2022-10-02 19:00:03October 2, 2022 | TRU Prep Academy Saints | 14 - 38 | CAI Knights | 2022 | N/A |
| 2022-10-01 19:00:29October 1, 2022 | IMG Academy National Ascenders | 19:00:29Canceled |  Jones | 2022 | N/A |
| 2022-10-01 19:00:16October 1, 2022 | First Academy Eagles | 20 - 46 | Cornerstone Charter Ducks | 2022 | N/A |
| 2022-10-01 18:30:15October 1, 2022 | Berean Christian Bulldogs | 14 - 10 | Country Day Spartans | 2022 | N/A |
| 2022-10-01 16:00:49October 1, 2022 | Somerset Academy Key Lions | 7 - 62 | Jupiter Christian School Eagles | 2022 | N/A |
| 2022-09-30 19:30:24September 30, 2022 | Port Orange Atlantic  | 26 - 8 |  Lake Weir Hurricanes | 2022 | N/A |
| 2022-09-30 19:00:42September 30, 2022 | Palm Beach Christian Saints | 19:00:42Canceled | Cocoa Beach Minutemen | 2022 | N/A |
| 2022-09-30 19:00:40September 30, 2022 | Bozeman Bucks | 24 - 34 | Freeport Bulldogs | 2022 | N/A |
| 2022-09-30 19:00:39September 30, 2022 | Sneads Pirates | 34 - 0 | Liberty County Bulldogs | 2022 | N/A |
| 2022-09-30 19:00:39September 30, 2022 | Community School of Naples Seahawks | 19:00:39Canceled | Oasis Sharks | 2022 | N/A |
| 2022-09-30 19:00:37September 30, 2022 | Avant Garde Sharks | 19:00:37Canceled | Legacy Charter Eagles | 2022 | N/A |
| 2022-09-30 19:00:33September 30, 2022 | Keswick Christian Crusaders | 19:00:33Canceled | Fort Myers Canterbury Cougars | 2022 | N/A |
| 2022-09-30 19:00:29September 30, 2022 | Baker Gators | 48 - 7 | Lighthouse PCA Stingrays | 2022 | N/A |
| 2022-09-30 19:00:28September 30, 2022 | Port St. Joe Tiger Sharks | 24 - 6 | Blountstown Tigers | 2022 | N/A |
| 2022-09-30 19:00:26September 30, 2022 | Vernon Yellow Jackets | 0 - 42 | Holmes County Blue Devils | 2022 | N/A |
| 2022-09-30 19:00:14September 30, 2022 | Lake Mary  | 19:00:14Canceled |  Mandarin Mustangs | 2022 | N/A |
| 2022-09-30 19:00:14September 30, 2022 | CFCA Eagles | 19:00:14Canceled | Foundation Academy Lions | 2022 | N/A |
| 2022-09-30 19:00:08September 30, 2022 | Bishop Moore  | 19:00:08Canceled | Lake Highland Prep Highlanders | 2022 | N/A |
| 2022-09-30 19:00:08September 30, 2022 | Hilliard Flashes | WIN - FORFEIT |  Beachside | 2022 | N/A |
| 2022-09-30 19:00:06September 30, 2022 | Classical Prep Lions | 19:00:067:00 pm | Peniel Academy Warriors | 2022 | N/A |
| 2022-09-30 19:00:06September 30, 2022 | Trenton Tigers | 19:00:06Canceled | Chiefland Indians | 2022 | N/A |
| 2022-09-30 19:00:05September 30, 2022 | Eagle's View Academy Warriors | 19:00:05Canceled | Deltona Trinity Christian Academy Eagles | 2022 | N/A |
| 2022-09-30 19:00:02September 30, 2022 | Cedar Creek Christian Saints | 19:00:02Canceled | Harvest Community School Warriors | 2022 | N/A |
| 2022-09-30 19:00:00September 30, 2022 | Cottondale Hornets | 30 - 14 | Wewahitchka Gators | 2022 | N/A |
