| 2025-11-28 18:00:00November 28, 2025 | Miami Palmetto Panthers | 65 - 41 | Goleman Gators | 2025 | N/A |
| 2025-11-28 18:30:00November 28, 2025 | Raines Vikings | 61 - 15 | Bishop Kenny Crusaders | 2025 | N/A |
| 2025-11-28 18:30:00November 28, 2025 | Chaminade-Madonna Lions  | 35 - 14 | True North Classical Academy Titans | 2025 | N/A |
| 2025-11-28 19:00:00November 28, 2025 | NMB Chargers | 20 - 6 | Miami B.T. Washington Tornadoes | 2025 | N/A |
| 2025-11-28 19:00:00November 28, 2025 | Dr. Joaquin Garcia Bulldogs | 40 - 0 | Westwood Academy Panthers | 2025 | N/A |
| 2025-11-28 19:00:00November 28, 2025 | Tate Aggies | 35 - 14 | Chiles Timberwolves | 2025 | N/A |
| 2025-11-28 19:00:00November 28, 2025 | Dunnellon  | 14 - 12 |  Palatka | 2025 | N/A |
| 2025-11-28 19:00:00November 28, 2025 | Port St. Joe Tiger Sharks | 33 - 20 | Holmes County Blue Devils | 2025 | N/A |
| 2025-11-28 19:00:00November 28, 2025 | Fort White Indians | BYE | Weekly Scores | 2025 | N/A |
| 2025-11-28 19:00:00November 28, 2025 | Blountstown Tigers | 30 - 3 | Pahokee Blue Devils | 2025 | N/A |
| 2025-11-28 19:00:00November 28, 2025 | St. Petersburg Catholic Barons | 13 - 42 | Cardinal Newman Crusaders | 2025 | N/A |
| 2025-11-28 19:00:00November 28, 2025 | Immaculata-La Salle Royal Lions | 17 - 20 | Cardinal Gibbons Chiefs | 2025 | N/A |
| 2025-11-28 19:00:00November 28, 2025 | Bishop Moore  | 31 - 28 |  Eau Gallie | 2025 | N/A |
| 2025-11-28 19:00:00November 28, 2025 | Archbishop McCarthy Mavericks | 20 - 25 | Plantation American Heritage Patriots | 2025 | N/A |
| 2025-11-28 19:00:00November 28, 2025 | St. Augustine  | 28 - 31 | Choctawhatchee Indians | 2025 | N/A |
| 2025-11-28 19:00:00November 28, 2025 | St. Thomas Aquinas Raiders  | 34 - 7 | McArthur Mustangs | 2025 | N/A |
| 2025-11-28 19:00:00November 28, 2025 | Ponte Vedra  | 27 - 10 |  Mainland | 2025 | N/A |
| 2025-11-28 19:00:00November 28, 2025 | West Boca Raton Bulls | 41 - 3 | Mitchell Mustangs | 2025 | N/A |
| 2025-11-28 19:00:00November 28, 2025 | Buchholz  | 27 - 20 |  Mandarin Mustangs | 2025 | N/A |
| 2025-11-28 19:00:00November 28, 2025 | DeLand  | 31 - 40 |  Lake Mary | 2025 | N/A |
| 2025-11-28 19:00:00November 28, 2025 | Bolles Bulldogs | 44 - 10 | Pensacola Catholic Crusaders | 2025 | N/A |
| 2025-11-28 19:30:00November 28, 2025 | Southridge Spartans | 27 - 30 | West Broward Bobcats | 2025 | N/A |
| 2025-11-28 19:30:00November 28, 2025 | Hawthorne  | 36 - 6 | Chiefland Indians | 2025 | N/A |
| 2025-11-28 19:30:00November 28, 2025 | Carrollwood Day Patriots | 30 - 28 |  Clearwater Central Catholic Marauders | 2025 | N/A |
| 2025-11-28 19:30:00November 28, 2025 | University Chrisitan | 12 - 27 | Jacksonville Trinity Christian | 2025 | N/A |
| 2025-11-28 19:30:00November 28, 2025 | Cardinal Mooney Cougars  | 49 - 29 | Lakewood Spartans | 2025 | N/A |
| 2025-11-28 19:30:00November 28, 2025 | Bradford  | 10 - 17 |  Cocoa | 2025 | N/A |
| 2025-11-28 19:30:00November 28, 2025 | Booker Tornadoes | 50 - 14 | Nature Coast Tech Sharks | 2025 | N/A |
| 2025-11-28 19:30:00November 28, 2025 | Tampa Jesuit Tigers | 21 - 22 | Port Charlotte Pirates | 2025 | N/A |
| 2025-11-28 19:30:00November 28, 2025 | Jones  | 24 - 10 | Lake Wales Highlanders | 2025 | N/A |
| 2025-11-28 19:30:00November 28, 2025 | Riverdale Raiders | 28 - 26 | Manatee Hurricanes | 2025 | N/A |
| 2025-11-28 19:30:00November 28, 2025 | Edgewater  | 14 - 27 |  Lakeland Dreadnaughts | 2025 | N/A |
| 2025-11-28 19:30:00November 28, 2025 | Armwood Fighting Hawks | 42 - 0 |  South Lake | 2025 | N/A |
| 2025-11-28 19:30:00November 28, 2025 | Vero Beach Fighting Indians | 49 - 23 |  Dr. Phillips | 2025 | N/A |
| 2025-11-28 19:30:00November 28, 2025 | Venice Indians  | 41 - 22 | Sumner Stingrays | 2025 | N/A |
| 2025-11-29 19:00:00November 29, 2025 | Northwestern Bulls | 50 - 29 | Miami Central Rockets | 2025 | N/A |
