| 2022-11-26 13:00:00November 26, 2022 | Edgewater  | 13 - 42 |  Jones | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Bishop Verot Vikings | 39 - 21 | Frostproof Bulldogs | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | South Sumter Raiders | 7 - 35 |  Cocoa | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Bolles Bulldogs | 21 - 14 | Raines Vikings | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Plantation American Heritage Patriots | 31 - 20 | Cardinal Gibbons Chiefs | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Miami Central Rockets | 34 - 20 |  Norland Vikings | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Columbia Tigers | 20 - 14 | Choctawhatchee Indians | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Lake Wales Highlanders | 26 - 9 | Zephyrhills Bulldogs | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Jensen Beach Falcons | 10 - 45 |  Mainland | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Naples Golden Eagles | 7 - 14 | Dunbar Tigers | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Tampa Jesuit Tigers | 31 - 0 | Largo Packers | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | St. Thomas Aquinas Raiders  | 35 - 7 | Blanche Ely Tigers | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Homestead Broncos  | 33 - 13 | Miramar Patriots | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Lakeland Dreadnaughts  | 41 - 6 |  Lake Minneola | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Vero Beach Fighting Indians | 7 - 31 |  Kissimmee Osceola | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Venice Indians  | 35 - 15 | Sarasota Riverview Rams | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | East Lake Eagles | 19 - 43 |  Ocoee | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Columbus Explorers  | 31 - 3 | Doral Academy Firebirds | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Bradford  | 28 - 17 | Baker County Wildcats | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Union County Tigers | 41 - 6 |  Lafayette | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Hawthorne  | 21 - 20 | Pahokee Blue Devils | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Trinity Catholic  | 48 - 7 |  P.K. Yonge | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | John Carroll Golden Rams | 14 - 7 | Lakeland Christian Vikings | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | First Baptist Academy Lions | 39 - 24 | Moore Haven Terriers | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Jacksonville Trinity Christian Academy Conquerors | 29 - 36 | University Chrisitan Fightin' Christians | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Clearwater Central Catholic Marauders  | 21 - 11 | Carrollwood Day Patriots | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Chaminade-Madonna Lions  | 49 - 16 | Cardinal Newman Crusaders | 2022 | N/A |
| 2022-11-25 19:30:00November 25, 2022 | Florida High Seminoles | 38 - 13 | Suwannee Bulldogs | 2022 | N/A |
| 2022-11-25 19:00:00November 25, 2022 | Apopka  | 30 - 23 |  Lake Mary | 2022 | N/A |
| 2022-11-25 19:00:00November 25, 2022 | Bartram Trail  | 20 - 21 |  Buchholz | 2022 | N/A |
| 2022-11-25 19:00:00November 25, 2022 | Clearwater Calvary Christian Warriors | 42 - 63 | Lakewood Spartans | 2022 | N/A |
| 2022-11-25 19:00:00November 25, 2022 | NFC Eagles | 35 - 40 | Munroe Day Bobcats | 2022 | N/A |
| 2022-11-25 19:00:00November 25, 2022 | Sneads Pirates | 14 - 49 | Blountstown Tigers | 2022 | N/A |
| 2022-11-25 19:00:00November 25, 2022 | Northview Chiefs | 42 - 6 | Chipley Tigers | 2022 | N/A |
| 2022-11-25 18:30:00November 25, 2022 | Palm Beach Central Broncos | 14 - 10 | Palm Beach Gardens Gators | 2022 | N/A |
| 2022-11-25 15:30:00November 25, 2022 | True North Classical Academy Titans | 58 - 37 | Palmer Trinity Falcons | 2022 | N/A |
