| 2025-11-20 18:30:00November 20, 2025 | Dr. Joaquin Garcia Bulldogs | 28 - 27 | Royal Palm Beach Wildcats | 2025 | N/A |
| 2025-11-20 19:00:00November 20, 2025 | Fort White Indians | 59 - 0 | Wildwood Wildcats | 2025 | N/A |
| 2025-11-20 19:00:00November 20, 2025 | Chiles Timberwolves | 28 - 7 | Land O' Lakes Gators | 2025 | N/A |
| 2025-11-20 19:00:00November 20, 2025 | Tate Aggies | 21 - 19 |  Bartram Trail | 2025 | N/A |
| 2025-11-20 19:00:00November 20, 2025 | Palm Beach Gardens Gators | 20 - 24 | Westwood Academy Panthers | 2025 | N/A |
| 2025-11-20 19:00:00November 20, 2025 | Moore Haven Terriers | 19:00:007:00 pm | Northview Chiefs | 2025 | N/A |
| 2025-11-20 19:00:00November 20, 2025 | Port St. Joe Tiger Sharks | 37 - 0 | Milton Central | 2025 | N/A |
| 2025-11-20 19:00:00November 20, 2025 | Holmes County Blue Devils | 28 - 14 | Union County Tigers | 2025 | N/A |
| 2025-11-20 19:30:00November 20, 2025 | Palatka  | 30 - 6 | Hudson Cobras | 2025 | N/A |
| 2025-11-20 19:30:00November 20, 2025 | Miami Central Rockets | 70 - 30 | Lely Trojans | 2025 | N/A |
| 2025-11-20 19:30:00November 20, 2025 | Hallandale Chargers | 22 - 33 | Miami B.T. Washington Tornadoes | 2025 | N/A |
| 2025-11-20 19:30:00November 20, 2025 | NMB Chargers | 42 - 0 |  Oasis | 2025 | N/A |
| 2025-11-20 19:30:00November 20, 2025 | Dunnellon  | 40 - 24 | Andrew Jackson Tigers | 2025 | N/A |
| 2025-11-21 13:00:00November 21, 2025 | Bradenton Christian  | 14 - 38 |  Real Life Christian | 2025 | N/A |
| 2025-11-21 18:30:00November 21, 2025 | Raines Vikings | 54 - 0 | West Florida Jaguars | 2025 | N/A |
| 2025-11-21 19:00:00November 21, 2025 | Cardinal Mooney Cougars  | 51 - 14 | Bishop Verot Vikings | 2025 | N/A |
| 2025-11-21 19:00:00November 21, 2025 | Vero Beach Fighting Indians | 56 - 14 |  Lake Nona | 2025 | N/A |
| 2025-11-21 19:00:00November 21, 2025 | Ponte Vedra  | 38 - 3 |  Beachside | 2025 | N/A |
| 2025-11-21 19:00:00November 21, 2025 | Booker Tornadoes | 68 - 0 | Bayshore Bruins | 2025 | N/A |
| 2025-11-21 19:00:00November 21, 2025 | Bishop Kenny Crusaders | 55 - 37 | Godby Cougars | 2025 | N/A |
| 2025-11-21 19:00:00November 21, 2025 | Bolles Bulldogs | 51 - 27 | Florida High Seminoles | 2025 | N/A |
| 2025-11-21 19:00:00November 21, 2025 | West Nassau  | 41 - 51 |  Delray Beach American Heritage | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Eau Gallie  | 35 - 14 |  Merritt Island | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Tampa Jesuit Tigers | 45 - 7 | Naples Golden Eagles | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Nature Coast Tech Sharks | 20 - 7 | Jefferson Dragons | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Northwestern Bulls | 56 - 6 | Key West Conchs | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Mainland  | 36 - 31 | Mosley Dolphins | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Edgewater  | 21 - 0 | Tampa Bay Tech Titans | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Lakeland Dreadnaughts  | 15 - 8 | Gaither Cowboys | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Riverdale Raiders | 21 - 14 | Immokalee Indians | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Cape Coral Seahawks | 29 - 55 | Manatee Hurricanes | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | St. Thomas Aquinas Raiders  | 45 - 13 | Coconut Creek Cougars | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Delray Beach Atlantic Eagles | 16 - 17 | McArthur Mustangs | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Buchholz  | 29 - 17 |  Nease | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Mandarin Mustangs  | 42 - 35 | Pace Patriots | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Armwood Fighting Hawks | 49 - 0 |  Viera | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | South Lake  | 19 - 13 |  Kissimmee Osceola | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Palmetto Tigers | 7 - 9 | Mitchell Mustangs | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | West Boca Raton Bulls | 48 - 7 | East Lake Eagles | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Southridge Spartans | 42 - 6 | Piper Bengals | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | West Broward Bobcats | 38 - 12 | Monarch Knights | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | DeLand  | 65 - 17 |  Boone | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Lake Mary  | 50 - 20 |  Spruce Creek | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Venice Indians  | 70 - 35 |  West Orange | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Sarasota Riverview Rams | 21 - 31 | Sumner Stingrays | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Fort Pierce Central Cobras | 21 - 22 |  Dr. Phillips | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Miami Palmetto Panthers | 27 - 10 |  Columbus Explorers | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Spanish River Sharks | 42 - 56 | Goleman Gators | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Cardinal Gibbons Chiefs | 38 - 35 | Killian Cougars | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | University Chrisitan | 28 - 6 |  Impact Christian Academy | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Jacksonville Trinity Christian | 56 - 28 | Maclay Marauders | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Carrollwood Day Patriots | 49 - 6 |  Melbourne Central Catholic | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Clearwater Central Catholic Marauders  | 54 - 35 | Victory Christian Storm | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | St. Petersburg Catholic Barons | 50 - 46 | St. John Neumann Celtics | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Cardinal Newman Crusaders | 45 - 14 | Community School of Naples Seahawks | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Chaminade-Madonna Lions  | 47 - 18 | Edison Red Raiders | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | True North Classical Academy Titans | 62 - 28 | Saint Andrew's Scots | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Blountstown Tigers | 33 - 32 |  Madison County | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Taylor County | 7 - 17 | Pahokee Blue Devils | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Chiefland Indians | 49 - 19 | Baker Gators | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Hawthorne  | 30 - 8 | Williston Red Devils | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | St. Augustine  | 44 - 12 | Ed White Commanders | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Choctawhatchee Indians | 27 - 20 | Columbia Tigers | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Jones  | 29 - 18 |  Vanguard | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Zephyrhills Bulldogs | 35 - 47 | Lake Wales Highlanders | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Port Charlotte Pirates | 23 - 18 | Clearwater Tornadoes | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Archbishop McCarthy Mavericks | 24 - 14 |  Norland Vikings | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Plantation American Heritage Patriots | 48 - 7 | Plantation Colonels | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Pensacola Catholic Crusaders | 34 - 7 | South Walton Seahawks | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Bradford  | 24 - 14 |  Berkeley Prep Buccaneers | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Clearwater Calvary Christian Warriors | 33 - 34 |  Cocoa | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Lakewood Spartans | 14 - 7 | Glades Central Raiders | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Immaculata-La Salle Royal Lions | 42 - 16 | Ransom Everglades Raiders | 2025 | N/A |
| 2025-11-21 19:30:00November 21, 2025 | Bishop Moore  | 36 - 8 |  Eastside | 2025 | N/A |
| 2025-11-22 13:00:00November 22, 2025 | Oak Hall  | 27 - 10 |  Cambridge Christian | 2025 | N/A |
| 2025-11-22 13:00:00November 22, 2025 | All Saints Academy  | 36 - 22 |  St. Francis | 2025 | N/A |
| 2025-11-22 19:00:00November 22, 2025 | Jupiter Christian  | 41 - 19 |  Mount Dora Christian | 2025 | N/A |
