| 2022-09-27 19:00:35September 27, 2022 | Santa Fe Raiders | 0 - 15 | P.K. Yonge Blue Wave | 2022 | N/A |
| 2022-09-27 19:00:04September 27, 2022 | Menendez  | 23 - 14 |  Gainesville | 2022 | N/A |
| 2022-09-26 19:00:55September 26, 2022 | Yulee Hornets | 49 - 6 | Tradition Prep Pirates | 2022 | N/A |
| 2022-09-24 16:45:16September 24, 2022 | Lake Mary Prep Griffins | 37 - 31 | Four Corners Charter Coyotes | 2022 | N/A |
| 2022-09-24 14:00:14September 24, 2022 | Riverside(CA) CSDR Cubs | 84 - 8 | FSDB Dragons | 2022 | N/A |
| 2022-09-23 20:00:04September 23, 2022 | Phenix City(AL) Central Red Devils | 26 - 41 | IMG Academy National Ascenders | 2022 | N/A |
| 2022-09-23 19:30:57September 23, 2022 | Hamilton County Trojans | 38 - 21 | Bell Bulldogs | 2022 | N/A |
| 2022-09-23 19:30:40September 23, 2022 | Lafayette Hornets | 34 - 14 | Zarephath Academy Eagles | 2022 | N/A |
| 2022-09-23 19:00:59September 23, 2022 | American Collegiate Academy Rough Riders | 0 - 27 | IMG Academy Varsity White Ascenders | 2022 | N/A |
| 2022-09-23 19:00:58September 23, 2022 | Port Orange Atlantic  | 0 - 7 |  Matanzas | 2022 | N/A |
| 2022-09-23 19:00:58September 23, 2022 | Cornerstone Charter Ducks | 35 - 0 | Bronson Eagles | 2022 | N/A |
| 2022-09-23 19:00:58September 23, 2022 | Berean Christian Bulldogs | 6 - 28 | Bell Creek Academy Panthers | 2022 | N/A |
| 2022-09-23 19:00:57September 23, 2022 | Trinity Catholic Celtics  | 17 - 20 | Raines Vikings | 2022 | N/A |
| 2022-09-23 19:00:56September 23, 2022 | Flagler Palm Coast  | 19 - 21 |  Orange City University | 2022 | N/A |
| 2022-09-23 19:00:56September 23, 2022 | CFCA Eagles | FORFEIT - WIN | Seffner Christian Crusaders | 2022 | N/A |
| 2022-09-23 19:00:56September 23, 2022 | Gateway Charter Griffins | 8 - 21 | Fort Myers Gateway Eagles | 2022 | N/A |
| 2022-09-23 19:00:55September 23, 2022 | Riverside Christian School Wranglers | FORFEIT - WIN | Cedar Creek Christian Saints | 2022 | N/A |
| 2022-09-23 19:00:54September 23, 2022 | Lyman  | 28 - 47 | Lakewood Ranch Mustangs | 2022 | N/A |
| 2022-09-23 19:00:54September 23, 2022 | Oasis Sharks | 8 - 10 | Bradenton Christian Panthers | 2022 | N/A |
| 2022-09-23 19:00:54September 23, 2022 | Celebration  | 16 - 40 | Winter Haven Blue Devils | 2022 | N/A |
| 2022-09-23 19:00:53September 23, 2022 | St. John Lutheran Saints | 0 - 49 | All Saints Academy Saints | 2022 | N/A |
| 2022-09-23 19:00:51September 23, 2022 | Seabreeze  | 20 - 44 |  DeLand | 2022 | N/A |
| 2022-09-23 19:00:51September 23, 2022 | Bartram Trail  | 59 - 37 |  St. Augustine | 2022 | N/A |
| 2022-09-23 19:00:51September 23, 2022 | Wildwood Wildcats | 72 - 0 | A'kelynn's Angels Christian Academy Wildcats | 2022 | N/A |
| 2022-09-23 19:00:50September 23, 2022 | Orlando Cypress Creek Bears | 40 - 7 | Colonial Grenadiers | 2022 | N/A |
| 2022-09-23 19:00:48September 23, 2022 | Vanguard  | 21 - 24 |  Buchholz | 2022 | N/A |
| 2022-09-23 19:00:48September 23, 2022 | Blountstown Tigers | 22 - 18 | Taylor County Bulldogs | 2022 | N/A |
| 2022-09-23 19:00:47September 23, 2022 | Oviedo  | 28 - 7 |  Timber Creek | 2022 | N/A |
| 2022-09-23 19:00:47September 23, 2022 | Hilliard Flashes | 30 - 14 | Crescent City Raiders | 2022 | N/A |
| 2022-09-23 19:00:47September 23, 2022 | Academy At The Lakes Wildcats | 20 - 12 | Real Life Christian Raptors | 2022 | N/A |
| 2022-09-23 19:00:47September 23, 2022 | Geneva Classical Academy Knights | 30 - 16 | Cornerstone Academy Cougars | 2022 | N/A |
| 2022-09-23 19:00:46September 23, 2022 | Deltona  | 44 - 6 | Liberty Chargers | 2022 | N/A |
| 2022-09-23 19:00:46September 23, 2022 | Newberry Panthers | 0 - 45 | Union County Tigers | 2022 | N/A |
| 2022-09-23 19:00:46September 23, 2022 | Master's Academy Patriots | FORFEIT - WIN | Duval Charter School Panthers | 2022 | N/A |
| 2022-09-23 19:00:46September 23, 2022 | St. Johns Country Day Spartans | 29 - 26 | Calvary Chapel Eagles | 2022 | N/A |
| 2022-09-23 19:00:46September 23, 2022 | Northside Christian Mustangs | 38 - 6 | West Oaks Academy Flames | 2022 | N/A |
| 2022-09-23 19:00:45September 23, 2022 | Chiles Timberwolves | 27 - 23 |  Oakleaf | 2022 | N/A |
| 2022-09-23 19:00:44September 23, 2022 | Satellite  | 27 - 0 | Astronaut War Eagles | 2022 | N/A |
| 2022-09-23 19:00:44September 23, 2022 | Santa Fe Raiders | 14 - 7 | Gainesville | 2022 | N/A |
| 2022-09-23 19:00:43September 23, 2022 | West Port  | 26 - 0 | Kissimmee Gateway Panthers | 2022 | N/A |
| 2022-09-23 19:00:42September 23, 2022 | Ridgeview  | 15 - 42 |  Beachside | 2022 | N/A |
| 2022-09-23 19:00:42September 23, 2022 | Edgewater  | 28 - 19 |  Apopka | 2022 | N/A |
| 2022-09-23 19:00:41September 23, 2022 | Space Coast Vipers | 7 - 46 |  Tohopekaliga | 2022 | N/A |
| 2022-09-23 19:00:40September 23, 2022 | North Marion  | 7 - 10 | Suwannee Bulldogs | 2022 | N/A |
| 2022-09-23 19:00:38September 23, 2022 | Lake Weir Hurricanes  | 0 - 36 | Palatka Panthers | 2022 | N/A |
| 2022-09-23 19:00:37September 23, 2022 | Ambassadors Christian Academy Stallions | 22 - 12 | Roar Prep & Vocational Academy Lions | 2022 | N/A |
| 2022-09-23 19:00:37September 23, 2022 | Wewahitchka Gators | 0 - 28 | Bozeman Bucks | 2022 | N/A |
| 2022-09-23 19:00:36September 23, 2022 | Lake Highland Prep Highlanders | 60 - 0 | Trinity Prep Saints | 2022 | N/A |
| 2022-09-23 19:00:36September 23, 2022 | Viera  | 14 - 34 | Baker County Wildcats | 2022 | N/A |
| 2022-09-23 19:00:34September 23, 2022 | Ocoee  | 47 - 12 |  Orlando Freedom | 2022 | N/A |
| 2022-09-23 19:00:33September 23, 2022 | Rockledge  | 7 - 30 |  Kissimmee Osceola | 2022 | N/A |
| 2022-09-23 19:00:33September 23, 2022 | Eau Gallie  | 28 - 13 |  Harmony | 2022 | N/A |
| 2022-09-23 19:00:31September 23, 2022 | Sarasota Christian Blazers | 57 - 26 | Foundation Christian Panthers | 2022 | N/A |
| 2022-09-23 19:00:30September 23, 2022 | Interlachen Rams  | 26 - 12 | Keystone Heights Indians | 2022 | N/A |
| 2022-09-23 19:00:30September 23, 2022 | Mount Dora Christian Bulldogs | 29 - 6 |  Tavares | 2022 | N/A |
| 2022-09-23 19:00:29September 23, 2022 | Pine Ridge  | 12 - 14 |  Lake Howell | 2022 | N/A |
| 2022-09-23 19:00:29September 23, 2022 | Harvest Community School Warriors | 18 - 22 | Bishop Snyder Cardinals | 2022 | N/A |
| 2022-09-23 19:00:28September 23, 2022 | Merritt Island  | 6 - 20 |  Heritage | 2022 | N/A |
| 2022-09-23 19:00:26September 23, 2022 | Mulberry Panthers | 41 - 21 | Santa Fe Catholic Hawks | 2022 | N/A |
| 2022-09-23 19:00:26September 23, 2022 | Countryside Christian Minutemen | 60 - 13 | Old Plank Christian Defenders | 2022 | N/A |
| 2022-09-23 19:00:25September 23, 2022 | Bradford Tornadoes  | 21 - 7 | Munroe Day Bobcats | 2022 | N/A |
| 2022-09-23 19:00:25September 23, 2022 | Melbourne Central Catholic Hustlers | 3 - 59 |  Titusville | 2022 | N/A |
| 2022-09-23 19:00:25September 23, 2022 | Port St. Joe Tiger Sharks | 34 - 0 | Rutherford Rams | 2022 | N/A |
| 2022-09-23 19:00:25September 23, 2022 | Sneads Pirates | 38 - 20 | Colquitt(GA) Miller County Pirates | 2022 | N/A |
| 2022-09-23 19:00:24September 23, 2022 | Melbourne  | 3 - 44 |  Cocoa | 2022 | N/A |
| 2022-09-23 19:00:24September 23, 2022 | Hawthorne Hornets  | 46 - 6 | P.K. Yonge Blue Wave | 2022 | N/A |
| 2022-09-23 19:00:23September 23, 2022 | Westminster Academy Lions | 48 - 6 | St. Edward's Pirates | 2022 | N/A |
| 2022-09-23 19:00:22September 23, 2022 | Ponte Vedra  | 34 - 12 | Menendez | 2022 | N/A |
| 2022-09-23 19:00:22September 23, 2022 | Lake Brantley  | 17 - 12 |  Wekiva | 2022 | N/A |
| 2022-09-23 19:00:20September 23, 2022 | Venice Indians  | 24 - 17 |  Sanford Seminole | 2022 | N/A |
| 2022-09-23 19:00:20September 23, 2022 | Lakeside Christian Lions | 48 - 8 | City of Life Christian Warriors | 2022 | N/A |
| 2022-09-23 19:00:19September 23, 2022 | Ridge Community Bolts | 53 - 27 |  East Ridge | 2022 | N/A |
| 2022-09-23 19:00:18September 23, 2022 | Foundation Academy Lions | 14 - 57 | Orlando Christian Prep Warriors | 2022 | N/A |
| 2022-09-23 19:00:18September 23, 2022 | Holmes County Blue Devils | 42 - 23 | Jay Royals | 2022 | N/A |
| 2022-09-23 19:00:17September 23, 2022 | Windermere Wolverines  | 21 - 18 | Lake Buena Vista Vipers | 2022 | N/A |
| 2022-09-23 19:00:17September 23, 2022 | The Classical Academy Patriots | 0 - 52 | St. Petersburg Canterbury Crusaders | 2022 | N/A |
| 2022-09-23 19:00:15September 23, 2022 | Halifax Academy Knights | 0 - 34 | Cocoa Beach Minutemen | 2022 | N/A |
| 2022-09-23 19:00:15September 23, 2022 | Eagle's View Academy Warriors | 0 - 35 | Oak Hall Eagles | 2022 | N/A |
| 2022-09-23 19:00:15September 23, 2022 | Palm Bay  | 14 - 7 | Fort Pierce Central Cobras | 2022 | N/A |
| 2022-09-23 19:00:14September 23, 2022 | Lighthouse PCA Stingrays | 8 - 7 | Destin Sharks | 2022 | N/A |
| 2022-09-23 19:00:13September 23, 2022 | Keswick Christian Crusaders | 28 - 8 | Deltona Trinity Christian Academy Eagles | 2022 | N/A |
| 2022-09-23 19:00:10September 23, 2022 | Holy Trinity Tigers | 31 - 8 | Faith Christian Academy Lions | 2022 | N/A |
| 2022-09-23 19:00:09September 23, 2022 | Forest  | 18 - 20 |  Dunnellon | 2022 | N/A |
| 2022-09-23 19:00:09September 23, 2022 | Village View Christian Eagles | 19:00:097:00 pm | Classical Prep Lions | 2022 | N/A |
| 2022-09-23 19:00:08September 23, 2022 | Boone  | 24 - 34 |  Dr. Phillips | 2022 | N/A |
| 2022-09-23 19:00:07September 23, 2022 | John Carroll Golden Rams | 28 - 17 |  Bishop Moore | 2022 | N/A |
| 2022-09-23 19:00:06September 23, 2022 | First Academy Eagles | 8 - 49 | Out-Of-Door Academy Thunder | 2022 | N/A |
| 2022-09-23 19:00:06September 23, 2022 | Hope Christian Lions | 6 - 47 |  Gainesville Christian Warriors | 2022 | N/A |
| 2022-09-23 19:00:05September 23, 2022 | Boca Raton Christian Blazers | 13 - 49 | Jupiter Christian School Eagles | 2022 | N/A |
| 2022-09-23 19:00:05September 23, 2022 | Lake Minneola  | 26 - 39 |  Mainland | 2022 | N/A |
| 2022-09-23 19:00:05September 23, 2022 | St. Francis Catholic Wolves | 8 - 52 | Seven Rivers Christian Warriors | 2022 | N/A |
| 2022-09-23 19:00:04September 23, 2022 | Shorecrest Prep Chargers | 46 - 0 |  Merritt Island Christian Cougars | 2022 | N/A |
| 2022-09-23 19:00:03September 23, 2022 | Jones  | 17 - 14 |  West Orange | 2022 | N/A |
| 2022-09-23 19:00:03September 23, 2022 | Orange Park  | 12 - 27 |  Nease | 2022 | N/A |
| 2022-09-23 19:00:03September 23, 2022 | Hagerty  | 45 - 7 | East River Falcons | 2022 | N/A |
| 2022-09-23 19:00:02September 23, 2022 | Poinciana Eagles  | 20 - 2 | Tenoroc Titans | 2022 | N/A |
| 2022-09-23 19:00:02September 23, 2022 | The Villages Charter Buffalo | 38 - 6 |  Leesburg | 2022 | N/A |
| 2022-09-23 19:00:02September 23, 2022 | Evans  | 10 - 37 |  Winter Park | 2022 | N/A |
| 2022-09-23 19:00:02September 23, 2022 | Pine Crest Panthers | 21 - 20 | Windermere Prep Lakers | 2022 | N/A |
| 2022-09-23 19:00:01September 23, 2022 | Jordan Christian Prep Seahawks | 0 - 42 | Saint Stephen's Episcopal Falcons | 2022 | N/A |
| 2022-09-23 19:00:01September 23, 2022 | CAI Knights | 34 - 15 | Palmetto Tigers | 2022 | N/A |
| 2022-09-23 19:00:00September 23, 2022 | Ribault Trojans | 20 - 35 |  Middleburg | 2022 | N/A |
| 2022-09-23 19:00:00September 23, 2022 | Clay County  | 21 - 26 |  Tocoi Creek | 2022 | N/A |
| 2022-09-23 18:30:47September 23, 2022 | Stanton Prep Blue Devils | 0 - 36 | Englewood Rams | 2022 | N/A |
| 2022-09-23 18:30:14September 23, 2022 | Paxon Golden Eagles | 21 - 22 | Branford Buccaneers | 2022 | N/A |
| 2022-09-23 18:30:08September 23, 2022 | Mandarin Mustangs  | 27 - 37 |  Creekside | 2022 | N/A |
| 2022-09-23 18:00:43September 23, 2022 | Ocala Christian Crusaders | 2 - 44 | Donahue Academy Shamrocks | 2022 | N/A |
| 2022-09-22 19:00:43September 22, 2022 | Mount Dora  | 48 - 47 |  South Lake | 2022 | N/A |
| 2022-09-22 19:00:42September 22, 2022 | Tradition Prep Pirates | 16 - 48 | Coral Springs Charter Panthers | 2022 | N/A |
| 2022-09-22 19:00:25September 22, 2022 | Orlando University Cougars | 0 - 42 | Highlands Ranch(CO) Mountain Vista Golden Eagles | 2022 | N/A |
| 2022-09-22 19:00:20September 22, 2022 | Moore Haven Terriers | 41 - 15 | IMG Academy Varsity Blue Ascenders | 2022 | N/A |
| 2022-09-22 19:00:07September 22, 2022 | St. Cloud  | 38 - 16 |  Winter Springs | 2022 | N/A |
| 2022-09-22 15:00:23September 22, 2022 | TRU Prep Academy Saints | WIN - FORFEIT | Hialeah Thoroughbreds | 2022 | N/A |
