| 2022-12-02 19:30:00December 2, 2022 | Venice Indians  | 42 - 35 | Buchholz Bobcats | 2022 | N/A |
| 2022-12-02 19:30:00December 2, 2022 | St. Thomas Aquinas Raiders  | 45 - 3 | Tampa Jesuit Tigers | 2022 | N/A |
| 2022-12-02 19:30:00December 2, 2022 | Hawthorne Hornets  | 28 - 0 | Blountstown Tigers | 2022 | N/A |
| 2022-12-02 19:30:00December 2, 2022 | Northview Chiefs | 21 - 11 | Union County Tigers | 2022 | N/A |
| 2022-12-02 19:30:00December 2, 2022 | First Baptist Academy Lions | 28 - 7 | Munroe Day Bobcats | 2022 | N/A |
| 2022-12-02 19:30:00December 2, 2022 | Bradford Tornadoes  | 21 - 31 |  Cocoa Tigers | 2022 | N/A |
| 2022-12-02 19:30:00December 2, 2022 | Florida High Seminoles | 38 - 28 | Bishop Verot Vikings | 2022 | N/A |
| 2022-12-02 19:30:00December 2, 2022 | Dunbar Tigers | 23 - 30 |  Mainland Buccaneers | 2022 | N/A |
| 2022-12-02 19:30:00December 2, 2022 | Lake Wales Highlanders | 37 - 7 | Columbia Tigers | 2022 | N/A |
| 2022-12-02 19:30:00December 2, 2022 | Lakeland Dreadnaughts  | 14 - 7 |  Kissimmee Osceola Kowboys | 2022 | N/A |
| 2022-12-02 19:30:00December 2, 2022 | Chaminade-Madonna Lions  | 56 - 0 | True North Classical Academy Titans | 2022 | N/A |
| 2022-12-02 19:30:00December 2, 2022 | University Chrisitan Fightin' Christians | 29 - 35 |  Clearwater Central Catholic Marauders | 2022 | N/A |
| 2022-12-02 19:30:00December 2, 2022 | Miami Central Rockets | 39 - 21 | Lakewood Spartans | 2022 | N/A |
| 2022-12-02 19:30:00December 2, 2022 | Plantation American Heritage Patriots | 21 - 14 | Bolles Bulldogs | 2022 | N/A |
| 2022-12-02 19:00:00December 2, 2022 | Palm Beach Central Broncos | 24 - 27 |  Apopka Blue Darters | 2022 | N/A |
| 2022-12-02 19:00:00December 2, 2022 | Jones Tigers  | 24 - 30 |  Homestead Broncos | 2022 | N/A |
| 2022-12-02 19:00:00December 2, 2022 | Trinity Catholic Celtics  | 22 - 10 | John Carroll Golden Rams | 2022 | N/A |
| 2022-12-02 19:00:00December 2, 2022 | Columbus Explorers  | 41 - 36 |  Ocoee Knights | 2022 | N/A |
