| 2022-08-22 17:30:52August 22, 2022 | Real Life Christian Raptors | 23 - 24 | Eastland Christian Hurricanes | 2022 | N/A |
| 2022-08-20 19:00:09August 20, 2022 | Jones  | 24 - 42 | Northwestern Bulls | 2022 | N/A |
| 2022-08-20 12:00:12August 20, 2022 | St. Augustine  | 13 - 0 |  Spruce Creek | 2022 | N/A |
| 2022-08-20 11:00:45August 20, 2022 | Seven Rivers Christian Warriors | 21 - 0 | Trinity Prep Saints | 2022 | N/A |
| 2022-08-19 19:30:55August 19, 2022 | Bell Bulldogs | 0 - 49 | Lafayette Hornets | 2022 | N/A |
| 2022-08-19 19:30:18August 19, 2022 | Hamilton County Trojans | 0 - 40 | NFC Eagles | 2022 | N/A |
| 2022-08-19 19:30:07August 19, 2022 | Vanguard  | 49 - 0 |  Eustis | 2022 | N/A |
| 2022-08-19 19:00:59August 19, 2022 | Windermere Wolverines  | 19:00:59Canceled |  St. Cloud | 2022 | N/A |
| 2022-08-19 19:00:57August 19, 2022 | Coral Springs Colts | 0 - 49 |  Ocoee | 2022 | N/A |
| 2022-08-19 19:00:56August 19, 2022 | Clay County  | 12 - 47 | Bishop Kenny Crusaders | 2022 | N/A |
| 2022-08-19 19:00:55August 19, 2022 | Dunnellon  | 12 - 0 | Lecanto Panthers | 2022 | N/A |
| 2022-08-19 19:00:53August 19, 2022 | Bartram Trail  | 40 - 0 | Riverside Generals | 2022 | N/A |
| 2022-08-19 19:00:51August 19, 2022 | Manatee Hurricanes | 30 - 21 | IMG Academy Varsity White Ascenders | 2022 | N/A |
| 2022-08-19 19:00:51August 19, 2022 | East Ridge  | 19:00:51Canceled | Tenoroc Titans | 2022 | N/A |
| 2022-08-19 19:00:51August 19, 2022 | Ocala Christian Crusaders | 26 - 8 | Lake Mary Prep Griffins | 2022 | N/A |
| 2022-08-19 19:00:50August 19, 2022 | Apopka  | 19:00:50Canceled |  Kissimmee Osceola | 2022 | N/A |
| 2022-08-19 19:00:50August 19, 2022 | Bolles Bulldogs | 41 - 13 |  Orange Park | 2022 | N/A |
| 2022-08-19 19:00:50August 19, 2022 | Bishop Moore  | 19:00:50Canceled | Rickards Raiders | 2022 | N/A |
| 2022-08-19 19:00:49August 19, 2022 | Tocoi Creek  | 20 - 0 | Paxon Golden Eagles | 2022 | N/A |
| 2022-08-19 19:00:49August 19, 2022 | Franklin County Seahawks | 14 - 0 | St. Francis Catholic Wolves | 2022 | N/A |
| 2022-08-19 19:00:49August 19, 2022 | Space Coast Vipers | 19:00:49Canceled |  Port Orange Atlantic | 2022 | N/A |
| 2022-08-19 19:00:48August 19, 2022 | The Master's Academy Eagles | 19:00:48Canceled | Foundation Academy Lions | 2022 | N/A |
| 2022-08-19 19:00:47August 19, 2022 | Lake Brantley  | 19:00:47Canceled |  Melbourne | 2022 | N/A |
| 2022-08-19 19:00:47August 19, 2022 | Merritt Island  | 0 - 36 |  Cocoa | 2022 | N/A |
| 2022-08-19 19:00:47August 19, 2022 | Newberry Panthers | 0 - 34 | Wildwood Wildcats | 2022 | N/A |
| 2022-08-19 19:00:47August 19, 2022 | Master's Academy Patriots | FORFEIT - WIN | Oasis Christian Lions | 2022 | N/A |
| 2022-08-19 19:00:47August 19, 2022 | Forest  | 13 - 19 | Fort Pierce Central Cobras | 2022 | N/A |
| 2022-08-19 19:00:46August 19, 2022 | St. John Lutheran Saints | 6 - 31 |  Merritt Island Christian Cougars | 2022 | N/A |
| 2022-08-19 19:00:46August 19, 2022 | Legacy Charter Eagles | 0 - 28 | Somerset Academy Pines Panthers | 2022 | N/A |
| 2022-08-19 19:00:45August 19, 2022 | Keswick Christian Crusaders | 0 - 49 | Out-Of-Door Academy Thunder | 2022 | N/A |
| 2022-08-19 19:00:44August 19, 2022 | DeLand  | 19:00:44Canceled |  Boone | 2022 | N/A |
| 2022-08-19 19:00:44August 19, 2022 | Tavares  | 19:00:44Canceled |  South Lake | 2022 | N/A |
| 2022-08-19 19:00:44August 19, 2022 | Hagerty  | 19:00:44Canceled |  Lake Nona | 2022 | N/A |
| 2022-08-19 19:00:44August 19, 2022 | Edgewater  | 19:00:44Canceled |  Sanford Seminole | 2022 | N/A |
| 2022-08-19 19:00:43August 19, 2022 | Orangewood Christian Rams | 19:00:43Canceled | American Collegiate Academy Rough Riders | 2022 | N/A |
| 2022-08-19 19:00:42August 19, 2022 | Palm Bay  | 21 - 7 |  Satellite | 2022 | N/A |
| 2022-08-19 19:00:42August 19, 2022 | Cardinal Newman Crusaders | 63 - 7 | Jupiter Christian School Eagles | 2022 | N/A |
| 2022-08-19 19:00:41August 19, 2022 | Santa Fe Catholic Hawks | 26 - 6 | Discovery Spartans | 2022 | N/A |
| 2022-08-19 19:00:40August 19, 2022 | Middleburg  | 35 - 14 | Episcopal School Eagles | 2022 | N/A |
| 2022-08-19 19:00:40August 19, 2022 | Archbishop McCarthy Mavericks | 35 - 6 | Boca Raton Christian Blazers | 2022 | N/A |
| 2022-08-19 19:00:39August 19, 2022 | Menendez  | 14 - 30 |  Nease | 2022 | N/A |
| 2022-08-19 19:00:39August 19, 2022 | TDH Christian Academy Eagles | 8 - 18 | West Oaks Academy Flames | 2022 | N/A |
| 2022-08-19 19:00:36August 19, 2022 | Orlando Freedom  | 19:00:36Canceled |  Harmony | 2022 | N/A |
| 2022-08-19 19:00:34August 19, 2022 | The First Academy Royals | 19:00:34Canceled | Lakeland Christian Vikings | 2022 | N/A |
| 2022-08-19 19:00:34August 19, 2022 | Mount Dora Christian Bulldogs | 19:00:34Canceled | Bishop Snyder Cardinals | 2022 | N/A |
| 2022-08-19 19:00:32August 19, 2022 | Flagler Palm Coast  | 27 - 0 | Atlantic Coast Stingrays | 2022 | N/A |
| 2022-08-19 19:00:32August 19, 2022 | Timber Creek  | 19:00:32Canceled |  Orange City University | 2022 | N/A |
| 2022-08-19 19:00:30August 19, 2022 | Oak Ridge Pioneers | 19:00:30Canceled |  Tohopekaliga | 2022 | N/A |
| 2022-08-19 19:00:29August 19, 2022 | Tarpon Springs Spongers | 42 - 6 | Cornerstone Charter Ducks | 2022 | N/A |
| 2022-08-19 19:00:28August 19, 2022 | Lake Mary  | 19:00:28Canceled | CAI Knights | 2022 | N/A |
| 2022-08-19 19:00:28August 19, 2022 | Liberty Chargers | 19:00:28Canceled | Lake Buena Vista Vipers | 2022 | N/A |
| 2022-08-19 19:00:28August 19, 2022 | Venice Indians  | 3 - 41 | IMG Academy National Ascenders | 2022 | N/A |
| 2022-08-19 19:00:28August 19, 2022 | St. John Neumann Celtics | 12 - 7 | Fort Myers Canterbury Cougars | 2022 | N/A |
| 2022-08-19 19:00:27August 19, 2022 | Port St. Joe Tiger Sharks | 41 - 0 | North Bay Haven Buccaneers | 2022 | N/A |
| 2022-08-19 19:00:22August 19, 2022 | Avon Park Red Devils | 16 - 28 |  Poinciana Eagles | 2022 | N/A |
| 2022-08-19 19:00:22August 19, 2022 | Evans  | 19:00:22Canceled | Orlando University Cougars | 2022 | N/A |
| 2022-08-19 19:00:21August 19, 2022 | CFCA Eagles | 19:00:21Canceled | Northside Christian Mustangs | 2022 | N/A |
| 2022-08-19 19:00:21August 19, 2022 | Treasure Coast Titans | 16 - 14 |  Rockledge | 2022 | N/A |
| 2022-08-19 19:00:21August 19, 2022 | Melbourne Central Catholic Hustlers | 7 - 28 | St. Edward's Pirates | 2022 | N/A |
| 2022-08-19 19:00:20August 19, 2022 | Ridgeview  | 20 - 22 | Keystone Heights Indians | 2022 | N/A |
| 2022-08-19 19:00:19August 19, 2022 | Bishop McLaughlin Hurricanes | 6 - 55 | Bradenton Christian Panthers | 2022 | N/A |
| 2022-08-19 19:00:18August 19, 2022 | Ponte Vedra  | 19 - 0 |  Mandarin Mustangs | 2022 | N/A |
| 2022-08-19 19:00:18August 19, 2022 | Mulberry Panthers | 32 - 6 | Cocoa Beach Minutemen | 2022 | N/A |
| 2022-08-19 19:00:16August 19, 2022 | Bozeman Bucks | 22 - 21 | Arnold Marlins | 2022 | N/A |
| 2022-08-19 19:00:15August 19, 2022 | North Marion  | 30 - 17 |  Gainesville | 2022 | N/A |
| 2022-08-19 19:00:14August 19, 2022 | Mount Dora  | 19:00:14Canceled | Palatka Panthers | 2022 | N/A |
| 2022-08-19 19:00:14August 19, 2022 | West Orange  | 19:00:14Canceled |  Winter Park | 2022 | N/A |
| 2022-08-19 19:00:13August 19, 2022 | Celebration  | 19:00:13Canceled | Davenport Broncos | 2022 | N/A |
| 2022-08-19 19:00:12August 19, 2022 | Dr. Phillips  | 19:00:12Canceled |  Lake Minneola | 2022 | N/A |
| 2022-08-19 19:00:12August 19, 2022 | Eau Gallie  | 32 - 0 |  Viera | 2022 | N/A |
| 2022-08-19 19:00:11August 19, 2022 | Winter Springs  | 19:00:11Canceled |  Pine Ridge | 2022 | N/A |
| 2022-08-19 19:00:11August 19, 2022 | Leesburg  | 6 - 26 | South Sumter Raiders | 2022 | N/A |
| 2022-08-19 19:00:10August 19, 2022 | Lyman  | 19:00:10Canceled | Colonial Grenadiers | 2022 | N/A |
| 2022-08-19 19:00:10August 19, 2022 | Matanzas  | 7 - 35 |  Mainland | 2022 | N/A |
| 2022-08-19 19:00:10August 19, 2022 | Interlachen Rams  | 8 - 0 | Wolfson Wolfpack | 2022 | N/A |
| 2022-08-19 19:00:09August 19, 2022 | Oviedo  | 19:00:09Canceled |  Deltona | 2022 | N/A |
| 2022-08-19 19:00:08August 19, 2022 | Heritage  | 13 - 20 | Jensen Beach Falcons | 2022 | N/A |
| 2022-08-19 19:00:07August 19, 2022 | Fleming Island  | 42 - 6 | Westside Wolverines | 2022 | N/A |
| 2022-08-19 19:00:07August 19, 2022 | Lake Howell  | 19:00:07Canceled | Orlando Cypress Creek Bears | 2022 | N/A |
| 2022-08-19 19:00:07August 19, 2022 | Olympia  | 19:00:07Canceled | Park Vista Cobras | 2022 | N/A |
| 2022-08-19 19:00:06August 19, 2022 | Trinity Catholic Celtics  | 14 - 55 |  Buchholz | 2022 | N/A |
| 2022-08-19 19:00:06August 19, 2022 | Westminster Academy Lions | 13 - 12 | Palm Beach Christian Saints | 2022 | N/A |
| 2022-08-19 19:00:06August 19, 2022 | Wewahitchka Gators | 6 - 21 | Maclay Marauders | 2022 | N/A |
| 2022-08-19 19:00:04August 19, 2022 | East River Falcons | 19:00:04Canceled | Astronaut War Eagles | 2022 | N/A |
| 2022-08-19 19:00:03August 19, 2022 | Pinellas Park Patriots | 7 - 42 |  Wekiva | 2022 | N/A |
| 2022-08-19 19:00:03August 19, 2022 | Old Plank Christian Defenders | 27 - 19 | Calvary Chapel Eagles | 2022 | N/A |
| 2022-08-19 19:00:02August 19, 2022 | P.K. Yonge Blue Wave | 13 - 14 | Oak Hall Eagles | 2022 | N/A |
| 2022-08-19 19:00:02August 19, 2022 | Marianna Bulldogs | 20 - 19 | Sneads Pirates | 2022 | N/A |
| 2022-08-19 19:00:00August 19, 2022 | Horizon  | 19:00:00Canceled | Kissimmee Gateway Panthers | 2022 | N/A |
| 2022-08-19 19:00:00August 19, 2022 | Ed White Commanders | 6 - 12 |  Hawthorne Hornets | 2022 | N/A |
| 2022-08-19 19:00:00August 19, 2022 | West Nassau Warriors | 28 - 22 | Santa Fe Raiders | 2022 | N/A |
| 2022-08-19 19:00:00August 19, 2022 | Chiefland Indians | 13 - 15 |  Eastside | 2022 | N/A |
| 2022-08-19 18:30:49August 19, 2022 | Stanton Prep Blue Devils | 42 - 6 | Eagle's View Academy Warriors | 2022 | N/A |
| 2022-08-19 18:30:26August 19, 2022 | Fletcher Senators | 21 - 24 |  Creekside | 2022 | N/A |
| 2022-08-19 18:30:09August 19, 2022 | Wellington Wolverines | 16 - 21 | Orlando Christian Prep Warriors | 2022 | N/A |
| 2022-08-18 19:30:25August 18, 2022 | Dixie County Bears | 33 - 13 | Riverside Christian School Wranglers | 2022 | N/A |
| 2022-08-18 19:00:54August 18, 2022 | Oasis Sharks | 31 - 20 | Halifax Academy Knights | 2022 | N/A |
| 2022-08-18 19:00:46August 18, 2022 | Umatilla Bulldogs | 19:00:46Canceled | Hudson Cobras | 2022 | N/A |
| 2022-08-18 19:00:45August 18, 2022 | IMG Academy Varsity Blue Ascenders | 32 - 6 | Faith Christian Academy Lions | 2022 | N/A |
| 2022-08-18 19:00:24August 18, 2022 | Florida High Seminoles | 42 - 0 | Blountstown Tigers | 2022 | N/A |
| 2022-08-18 19:00:07August 18, 2022 | Seabreeze  | 14 - 28 | Bayside Bears | 2022 | N/A |
| 2022-08-18 18:00:34August 18, 2022 | Saint Stephen's Episcopal Falcons | 31 - 20 | Southwest Florida Christian Academy King's | 2022 | N/A |
