| 2022-05-27 19:00:43May 27, 2022 | Jones  | 42 - 35 |  Rockledge | 2022 | N/A |
| 2022-05-27 18:30:54May 27, 2022 | Bradford  | 31 - 14 |  Oakleaf | 2022 | N/A |
| 2022-05-26 19:00:42May 26, 2022 | Heritage  | 28 - 28 |  Viera | 2022 | N/A |
| 2022-05-26 19:00:29May 26, 2022 | Tocoi Creek  | 13 - 44 | Yulee Hornets | 2022 | N/A |
| 2022-05-26 18:30:47May 26, 2022 | Clay County  | 14 - 35 |  Ponte Vedra | 2022 | N/A |
| 2022-05-26 18:00:44May 26, 2022 | Orangewood Christian  | 57 - 8 |  Halifax Academy | 2022 | N/A |
| 2022-05-25 19:00:31May 25, 2022 | Episcopal School Eagles | 56 - 12 |  St. Joseph Academy | 2022 | N/A |
| 2022-05-25 19:00:08May 25, 2022 | Mariner Tritons | 28 - 38 |  Gateway Charter | 2022 | N/A |
| 2022-05-25 19:00:06May 25, 2022 | Oasis  | 7 - 31 |  LaBelle | 2022 | N/A |
| 2022-05-23 19:00:51May 23, 2022 | Keystone Heights  | 6 - 28 |  Middleburg | 2022 | N/A |
| 2022-05-23 18:30:57May 23, 2022 | Fort White Indians | 23 - 31 |  Ridgeview | 2022 | N/A |
| 2022-05-21 19:00:58May 21, 2022 | Foundation Academy  | 19:00:58Canceled |  Seffner Christian | 2022 | N/A |
| 2022-05-21 13:00:26May 21, 2022 | Santa Fe Catholic  | 62 - 0 |  Deltona Trinity Christian | 2022 | N/A |
| 2022-05-20 19:30:43May 20, 2022 | Newberry  | 17 - 28 |  Gainesville | 2022 | N/A |
| 2022-05-20 19:30:17May 20, 2022 | Lake Region Thunder | 3 - 6 |  Liberty | 2022 | N/A |
| 2022-05-20 19:00:57May 20, 2022 | George Jenkins Eagles | 35 - 7 |  Celebration | 2022 | N/A |
| 2022-05-20 19:00:50May 20, 2022 | Nease  | 7 - 26 | Ed White Commanders | 2022 | N/A |
| 2022-05-20 19:00:46May 20, 2022 | Blountstown Tigers | 36 - 20 | Port St. Joe Tiger Sharks | 2022 | N/A |
| 2022-05-20 19:00:45May 20, 2022 | West Nassau  | 27 - 18 |  Paxon | 2022 | N/A |
| 2022-05-20 19:00:43May 20, 2022 | Ambassadors Christian Academy Stallions | 14 - 6 |  Faith Christian | 2022 | N/A |
| 2022-05-20 19:00:24May 20, 2022 | Kissimmee Gateway  | 6 - 20 |  Poinciana | 2022 | N/A |
| 2022-05-20 19:00:15May 20, 2022 | Columbia Tigers | 7 - 0 |  Bartram Trail | 2022 | N/A |
| 2022-05-20 19:00:03May 20, 2022 | Bishop Snyder  | 34 - 41 | Hilliard Flashes | 2022 | N/A |
| 2022-05-20 18:15:50May 20, 2022 | Wekiva  | 12 - 0 |  Norland Vikings | 2022 | N/A |
| 2022-05-20 18:00:57May 20, 2022 | Cornerstone Charter  | 17 - 6 |  Trinity Prep | 2022 | N/A |
| 2022-05-19 19:30:43May 19, 2022 | Santa Fe  | 21 - 14 | Dixie County Bears | 2022 | N/A |
| 2022-05-19 19:30:31May 19, 2022 | Dunnellon  | 2 - 45 | Wildwood Wildcats | 2022 | N/A |
| 2022-05-19 19:30:15May 19, 2022 | Bolles Bulldogs | 10 - 7 |  Deltona | 2022 | N/A |
| 2022-05-19 19:30:03May 19, 2022 | Lake Gibson Braves | 7 - 21 |  Apopka | 2022 | N/A |
| 2022-05-19 19:00:57May 19, 2022 | East River  | 12 - 7 |  Merritt Island | 2022 | N/A |
| 2022-05-19 19:00:54May 19, 2022 | Lake Buena Vista  | 14 - 21 |  Space Coast | 2022 | N/A |
| 2022-05-19 19:00:53May 19, 2022 | St. Francis  | 0 - 56 |  Riverside Christian | 2022 | N/A |
| 2022-05-19 19:00:52May 19, 2022 | Bishop Kenny Crusaders | 24 - 23 |  St. Augustine | 2022 | N/A |
| 2022-05-19 19:00:52May 19, 2022 | Weeki Wachee Hornets | 20 - 21 |  Lake Weir | 2022 | N/A |
| 2022-05-19 19:00:44May 19, 2022 | Menendez  | 14 - 12 | Westside Wolverines | 2022 | N/A |
| 2022-05-19 19:00:44May 19, 2022 | Winter Park  | 41 - 22 |  Seabreeze | 2022 | N/A |
| 2022-05-19 19:00:42May 19, 2022 | Bayshore Bruins | 28 - 7 |  Bradenton Christian | 2022 | N/A |
| 2022-05-19 19:00:37May 19, 2022 | North Marion  | 35 - 28 |  Trinity Catholic | 2022 | N/A |
| 2022-05-19 19:00:21May 19, 2022 | Lafayette  | 21 - 14 | Jefferson County Tigers | 2022 | N/A |
| 2022-05-19 19:00:19May 19, 2022 | Harmony  | 31 - 0 |  East Ridge | 2022 | N/A |
| 2022-05-19 19:00:15May 19, 2022 | Kissimmee Osceola  | 26 - 22 |  Edgewater | 2022 | N/A |
| 2022-05-19 19:00:03May 19, 2022 | Lakeland Christian Vikings | 34 - 14 |  Leesburg | 2022 | N/A |
| 2022-05-19 19:00:02May 19, 2022 | Buchholz  | 21 - 2 |  Vanguard | 2022 | N/A |
| 2022-05-19 18:30:39May 19, 2022 | Mandarin Mustangs  | 38 - 28 |  Fleming Island | 2022 | N/A |
| 2022-05-19 18:00:59May 19, 2022 | FSDB  | 28 - 54 |  Duval Charter | 2022 | N/A |
| 2022-05-19 18:00:59May 19, 2022 | Bishop McLaughlin  | 20 - 48 |  Seven Rivers Christian | 2022 | N/A |
| 2022-05-19 18:00:44May 19, 2022 | Oak Ridge  | 7 - 8 |  Colonial | 2022 | N/A |
| 2022-05-19 18:00:39May 19, 2022 | The King's Academy Lions | 53 - 16 |  St. Edward's | 2022 | N/A |
| 2022-05-19 18:00:36May 19, 2022 | Mount Dora Christian  | 0 - 8 |  Palm Beach Christian | 2022 | N/A |
| 2022-05-19 18:00:36May 19, 2022 | Lake Mary  | 21 - 7 |  Orange City University | 2022 | N/A |
| 2022-05-19 18:00:27May 19, 2022 | Holy Trinity  | 17 - 28 |  Satellite | 2022 | N/A |
| 2022-05-18 19:00:39May 18, 2022 | Moore Haven Terriers | 7 - 6 |  Westminster Academy | 2022 | N/A |
| 2022-05-18 18:00:27May 18, 2022 | South Lake  | 0 - 40 |  Eau Gallie | 2022 | N/A |
| 2022-05-17 19:00:34May 17, 2022 | Trenton Tigers | 6 - 42 |  Oak Hall | 2022 | N/A |
| 2022-05-17 18:30:32May 17, 2022 | Baker County Wildcats | 28 - 42 |  Creekside | 2022 | N/A |
| 2022-05-17 18:00:37May 17, 2022 | Umatilla  | 14 - 14 |  Palm Bay | 2022 | N/A |
| 2022-05-14 18:00:28May 14, 2022 | Wolfson Wolfpack | 28 - 6 |  Eagle's View Academy | 2022 | N/A |
| 2022-05-13 19:00:44May 13, 2022 | Astronaut  | 10 - 0 |  Windermere | 2022 | N/A |
| 2022-05-13 19:00:43May 13, 2022 | Eustis  | 28 - 14 | Crystal River Pirates | 2022 | N/A |
| 2022-05-13 18:30:39May 13, 2022 | Park Vista Cobras | 6 - 31 |  Melbourne | 2022 | N/A |
| 2022-05-12 19:00:42May 12, 2022 | Lake Nona  | 21 - 41 |  Timber Creek | 2022 | N/A |
| 2022-05-12 19:00:39May 12, 2022 | The Master's Academy  | 27 - 43 |  The First Academy | 2022 | N/A |
| 2022-05-12 19:00:32May 12, 2022 | CFCA  | 34 - 14 |  West Oaks Academy | 2022 | N/A |
| 2022-05-12 19:00:13May 12, 2022 | Zarephath Academy  | 0 - 21 |  Hawthorne | 2022 | N/A |
| 2022-05-12 19:00:09May 12, 2022 | Boca Raton St. John Paul II Eagles | 40 - 36 |  Jupiter Christian | 2022 | N/A |
| 2022-05-12 19:00:06May 12, 2022 | Tohopekaliga  | 12 - 38 |  Hagerty | 2022 | N/A |
| 2022-05-12 18:00:39May 12, 2022 | Saint Andrew's Scots | 40 - 0 |  Boca Raton Christian | 2022 | N/A |
