| 2022-09-20 17:30:42September 20, 2022 | Real Life Christian Raptors | 14 - 58 | Lakeside Christian Lions | 2022 | N/A |
| 2022-09-19 19:00:33September 19, 2022 | Oasis Sharks | 35 - 0 | Marco Island Academy Manta Rays | 2022 | N/A |
| 2022-09-19 19:00:27September 19, 2022 | Windermere Wolverines  | 7 - 35 |  Dr. Phillips | 2022 | N/A |
| 2022-09-19 19:00:20September 19, 2022 | Liberty Chargers | 0 - 32 | Davenport Broncos | 2022 | N/A |
| 2022-09-19 19:00:18September 19, 2022 | Lake Mary Prep Griffins | 36 - 6 | Eastland Christian Hurricanes | 2022 | N/A |
| 2022-09-19 18:00:44September 19, 2022 | Mainland  | 22 - 16 |  Flagler Palm Coast | 2022 | N/A |
| 2022-09-19 18:00:44September 19, 2022 | All Saints Academy Saints | 57 - 6 | The Classical Academy Patriots | 2022 | N/A |
| 2022-09-17 12:30:27September 17, 2022 | Seffner Christian Crusaders | 40 - 8 | Ambassadors Christian Academy Stallions | 2022 | N/A |
| 2022-09-17 11:00:39September 17, 2022 | Tampa Catholic Crusaders | 28 - 12 | American Collegiate Academy Rough Riders | 2022 | N/A |
| 2022-09-17 11:00:15September 17, 2022 | Lake Brantley  | 22 - 21 |  Lake Mary | 2022 | N/A |
| 2022-09-16 19:30:54September 16, 2022 | First Coast Christian Knights | 54 - 25 | Hope Christian Lions | 2022 | N/A |
| 2022-09-16 19:30:30September 16, 2022 | Hilliard Flashes | 14 - 21 | Lafayette Hornets | 2022 | N/A |
| 2022-09-16 19:30:15September 16, 2022 | Hamilton County Trojans | 6 - 45 | Fort White Indians | 2022 | N/A |
| 2022-09-16 19:00:59September 16, 2022 | Deltona Trinity Christian Academy Eagles | 0 - 47 | Seven Rivers Christian Warriors | 2022 | N/A |
| 2022-09-16 19:00:58September 16, 2022 | USCEDEA Stars | 19:00:587:00 pm | Village View Christian Eagles | 2022 | N/A |
| 2022-09-16 19:00:57September 16, 2022 | Ocoee  | 35 - 6 |  Olympia | 2022 | N/A |
| 2022-09-16 19:00:57September 16, 2022 | Lake Buena Vista Vipers | 7 - 13 | Oak Ridge Pioneers | 2022 | N/A |
| 2022-09-16 19:00:56September 16, 2022 | Deltona  | 32 - 13 |  Port Orange Atlantic | 2022 | N/A |
| 2022-09-16 19:00:56September 16, 2022 | Orangewood Christian Rams | 8 - 22 | The First Academy Royals | 2022 | N/A |
| 2022-09-16 19:00:56September 16, 2022 | Sanford Seminole  | 51 - 0 |  Evans | 2022 | N/A |
| 2022-09-16 19:00:56September 16, 2022 | Titusville  | 11 - 24 |  Palm Bay | 2022 | N/A |
| 2022-09-16 19:00:55September 16, 2022 | St. Francis Catholic Wolves | 12 - 2 | First Academy Eagles | 2022 | N/A |
| 2022-09-16 19:00:55September 16, 2022 | Master's Academy Patriots | FORFEIT - WIN | City of Life Christian Warriors | 2022 | N/A |
| 2022-09-16 19:00:54September 16, 2022 | Interlachen Rams  | 14 - 12 | Fernandina Beach Pirates | 2022 | N/A |
| 2022-09-16 19:00:54September 16, 2022 | Lakewood Ranch Mustangs | 28 - 7 |  Celebration | 2022 | N/A |
| 2022-09-16 19:00:53September 16, 2022 | Cocoa  | 76 - 0 | Space Coast Vipers | 2022 | N/A |
| 2022-09-16 19:00:53September 16, 2022 | Foundation Academy Lions | 21 - 7 | Mount Dora Christian Bulldogs | 2022 | N/A |
| 2022-09-16 19:00:53September 16, 2022 | Somerset Academy Canyons Cougars | 58 - 27 | Jupiter Christian School Eagles | 2022 | N/A |
| 2022-09-16 19:00:53September 16, 2022 | The Classical Academy Patriots | 6 - 52 | Countryside Christian Minutemen | 2022 | N/A |
| 2022-09-16 19:00:51September 16, 2022 | Leesburg  | 6 - 34 |  Vanguard | 2022 | N/A |
| 2022-09-16 19:00:51September 16, 2022 | Lake Highland Prep Highlanders | 42 - 0 | The Master's Academy Eagles | 2022 | N/A |
| 2022-09-16 19:00:50September 16, 2022 | Lyman  | 32 - 15 |  Lake Howell | 2022 | N/A |
| 2022-09-16 19:00:50September 16, 2022 | Gateway Charter Griffins | 0 - 29 | DeSoto County Bulldogs | 2022 | N/A |
| 2022-09-16 19:00:48September 16, 2022 | Middleburg  | 20 - 35 |  Ponte Vedra | 2022 | N/A |
| 2022-09-16 19:00:48September 16, 2022 | Tohopekaliga  | 47 - 6 |  St. Cloud | 2022 | N/A |
| 2022-09-16 19:00:47September 16, 2022 | Carrollwood Day Patriots | 19:00:47TBD |  Trinity Catholic Celtics | 2022 | N/A |
| 2022-09-16 19:00:45September 16, 2022 | Blountstown Tigers | 6 - 30 | Wakulla War Eagles | 2022 | N/A |
| 2022-09-16 19:00:44September 16, 2022 | Keystone Heights Indians | 38 - 12 | Impact Christian Academy Lions | 2022 | N/A |
| 2022-09-16 19:00:44September 16, 2022 | St. Joseph Academy Flashes | 8 - 16 | Eagle's View Academy Warriors | 2022 | N/A |
| 2022-09-16 19:00:42September 16, 2022 | Creekside  | 41 - 48 |  Buchholz | 2022 | N/A |
| 2022-09-16 19:00:42September 16, 2022 | Orlando Freedom  | 0 - 48 |  Boone | 2022 | N/A |
| 2022-09-16 19:00:42September 16, 2022 | Viera  | 12 - 31 |  Bishop Moore | 2022 | N/A |
| 2022-09-16 19:00:41September 16, 2022 | East River Falcons | 42 - 7 |  Winter Springs | 2022 | N/A |
| 2022-09-16 19:00:40September 16, 2022 | Boca Raton Christian Blazers | 35 - 8 | Berean Christian Bulldogs | 2022 | N/A |
| 2022-09-16 19:00:40September 16, 2022 | Halifax Academy Knights | 8 - 17 | Melbourne Central Catholic Hustlers | 2022 | N/A |
| 2022-09-16 19:00:40September 16, 2022 | Orlando Christian Prep Warriors | 11 - 14 |  Hawthorne Hornets | 2022 | N/A |
| 2022-09-16 19:00:39September 16, 2022 | Foundation Christian Panthers | 0 - 50 | Donahue Academy Shamrocks | 2022 | N/A |
| 2022-09-16 19:00:37September 16, 2022 | Satellite  | 21 - 49 |  Eau Gallie | 2022 | N/A |
| 2022-09-16 19:00:37September 16, 2022 | Timber Creek  | 7 - 10 |  Hagerty | 2022 | N/A |
| 2022-09-16 19:00:37September 16, 2022 | St. Johns Country Day Spartans | 27 - 26 | Ocala Christian Crusaders | 2022 | N/A |
| 2022-09-16 19:00:35September 16, 2022 | Santa Fe Raiders | 6 - 40 |  North Marion | 2022 | N/A |
| 2022-09-16 19:00:35September 16, 2022 | Out-Of-Door Academy Thunder | 50 - 0 | Bishop McLaughlin Hurricanes | 2022 | N/A |
| 2022-09-16 19:00:34September 16, 2022 | P.K. Yonge Blue Wave | 7 - 55 | Union County Tigers | 2022 | N/A |
| 2022-09-16 19:00:32September 16, 2022 | Pine Ridge  | 0 - 49 |  Orange City University | 2022 | N/A |
| 2022-09-16 19:00:31September 16, 2022 | Eustis  | 20 - 46 | South Sumter Raiders | 2022 | N/A |
| 2022-09-16 19:00:31September 16, 2022 | West Orange  | 13 - 25 |  Wekiva | 2022 | N/A |
| 2022-09-16 19:00:30September 16, 2022 | Nease  | 13 - 21 | Fletcher Senators | 2022 | N/A |
| 2022-09-16 19:00:30September 16, 2022 | Orlando Cypress Creek Bears | 0 - 28 |  Lake Nona | 2022 | N/A |
| 2022-09-16 19:00:29September 16, 2022 | Taylor Wildcats | 3 - 35 | Bell Bulldogs | 2022 | N/A |
| 2022-09-16 19:00:28September 16, 2022 | Menendez  | 7 - 35 |  St. Augustine | 2022 | N/A |
| 2022-09-16 19:00:27September 16, 2022 | Father Lopez Green Wave | 38 - 0 | Trinity Prep Saints | 2022 | N/A |
| 2022-09-16 19:00:26September 16, 2022 | Zephyrhills Bulldogs | 22 - 36 | IMG Academy Varsity White Ascenders | 2022 | N/A |
| 2022-09-16 19:00:24September 16, 2022 | Merritt Island  | 25 - 10 | Holy Trinity Tigers | 2022 | N/A |
| 2022-09-16 19:00:21September 16, 2022 | West Port  | 19 - 0 |  South Lake | 2022 | N/A |
| 2022-09-16 19:00:20September 16, 2022 | Orange Park  | 21 - 37 |  Melbourne | 2022 | N/A |
| 2022-09-16 19:00:18September 16, 2022 | Tavares  | 8 - 20 | Umatilla Bulldogs | 2022 | N/A |
| 2022-09-16 19:00:18September 16, 2022 | Harvest Community School Warriors | 9 - 51 | Wolfson Wolfpack | 2022 | N/A |
| 2022-09-16 19:00:17September 16, 2022 | Bradenton Christian Panthers | 0 - 34 | Evangelical Christian Sentinels | 2022 | N/A |
| 2022-09-16 19:00:16September 16, 2022 | Merritt Island Christian Cougars  | 44 - 12 | Calvary Chapel Eagles | 2022 | N/A |
| 2022-09-16 19:00:16September 16, 2022 | Lakeland Dreadnaughts  | 25 - 22 |  Kissimmee Osceola | 2022 | N/A |
| 2022-09-16 19:00:15September 16, 2022 | Bishop Snyder Cardinals | 34 - 6 | Cedar Creek Christian Saints | 2022 | N/A |
| 2022-09-16 19:00:14September 16, 2022 | East Ridge  | 7 - 60 |  Lake Minneola | 2022 | N/A |
| 2022-09-16 19:00:13September 16, 2022 | Ridgeview  | 10 - 60 |  Tocoi Creek | 2022 | N/A |
| 2022-09-16 19:00:13September 16, 2022 | Orlando University Cougars | 0 - 35 |  Winter Park | 2022 | N/A |
| 2022-09-16 19:00:12September 16, 2022 | Eastside  | 0 - 28 |  Bradford Tornadoes | 2022 | N/A |
| 2022-09-16 19:00:12September 16, 2022 | Legacy Charter Eagles | 6 - 37 | Indian Rocks Christian Golden Eagles | 2022 | N/A |
| 2022-09-16 19:00:12September 16, 2022 | Sebastian River Sharks | 19:00:12Canceled | St. Edward's Pirates | 2022 | N/A |
| 2022-09-16 19:00:11September 16, 2022 | Heritage  | 22 - 32 |  Oviedo | 2022 | N/A |
| 2022-09-16 19:00:11September 16, 2022 | Kissimmee Gateway Panthers | 0 - 47 | Auburndale Bloodhounds | 2022 | N/A |
| 2022-09-16 19:00:11September 16, 2022 | All Saints Academy Saints | 48 - 0 | Oasis Christian Lions | 2022 | N/A |
| 2022-09-16 19:00:10September 16, 2022 | Poinciana Eagles  | 6 - 22 |  Horizon | 2022 | N/A |
| 2022-09-16 19:00:10September 16, 2022 | Fort Myers Canterbury Cougars | 42 - 21 | Saint Stephen's Episcopal Falcons | 2022 | N/A |
| 2022-09-16 19:00:09September 16, 2022 | Liberty County Bulldogs | 56 - 0 | Franklin County Seahawks | 2022 | N/A |
| 2022-09-16 19:00:08September 16, 2022 | Lake Weir Hurricanes  | 0 - 14 | George Jenkins Eagles | 2022 | N/A |
| 2022-09-16 19:00:08September 16, 2022 | Port St. Joe Tiger Sharks | 45 - 0 | Troy(AL) Pike Liberal Arts Patriots | 2022 | N/A |
| 2022-09-16 19:00:07September 16, 2022 | Crystal River Pirates | 6 - 41 |  New Smyrna Beach | 2022 | N/A |
| 2022-09-16 19:00:07September 16, 2022 | Shorecrest Prep Chargers | 29 - 0 | Sarasota Christian Blazers | 2022 | N/A |
| 2022-09-16 19:00:06September 16, 2022 | Forest  | 31 - 19 |  Belleview | 2022 | N/A |
| 2022-09-16 19:00:06September 16, 2022 | Fleming Island  | 20 - 26 |  Oakleaf | 2022 | N/A |
| 2022-09-16 19:00:05September 16, 2022 | Jones  | 13 - 14 |  Edgewater | 2022 | N/A |
| 2022-09-16 19:00:04September 16, 2022 | Wewahitchka Gators | 22 - 14 | Trenton Tigers | 2022 | N/A |
| 2022-09-16 19:00:02September 16, 2022 | Pensacola Catholic Crusaders | 51 - 0 | Lighthouse PCA Stingrays | 2022 | N/A |
| 2022-09-16 19:00:02September 16, 2022 | Sneads Pirates | 46 - 33 | Holmes County Blue Devils | 2022 | N/A |
| 2022-09-16 19:00:01September 16, 2022 | Flagler Palm Coast | FORFEIT - WIN |  Matanzas | 2022 | N/A |
| 2022-09-16 19:00:01September 16, 2022 | Bayside Bears | 0 - 42 |  Rockledge | 2022 | N/A |
| 2022-09-16 18:30:20September 16, 2022 | Andrew Jackson Tigers | 35 - 6 |  Spruce Creek | 2022 | N/A |
| 2022-09-16 18:30:16September 16, 2022 | Paxon Golden Eagles | 41 - 6 | Stanton Prep Blue Devils | 2022 | N/A |
| 2022-09-16 18:00:39September 16, 2022 | YKIM Academy Ravens | 6 - 22 | West Oaks Academy Flames | 2022 | N/A |
| 2022-09-16 16:00:53September 16, 2022 | Duval Charter School Panthers | 35 - 12 | St. John Lutheran Saints | 2022 | N/A |
| 2022-09-15 19:00:57September 15, 2022 | Lincoln Trojans | 7 - 24 |  Bartram Trail | 2022 | N/A |
| 2022-09-15 19:00:52September 15, 2022 | IMG Academy Varsity Blue Ascenders | 14 - 0 | A'kelynn's Angels Christian Academy Wildcats | 2022 | N/A |
| 2022-09-15 19:00:51September 15, 2022 | Gainesville  | 10 - 28 |  Clay County | 2022 | N/A |
| 2022-09-15 19:00:40September 15, 2022 | FSDB Dragons | 6 - 30 | Old Plank Christian Defenders | 2022 | N/A |
| 2022-09-15 19:00:33September 15, 2022 | Westminster Academy Lions | 54 - 8 | WPB SLAM Cobras | 2022 | N/A |
| 2022-09-15 19:00:25September 15, 2022 | Palm Beach Christian Saints | 48 - 0 | Somerset Prep Hurricanes | 2022 | N/A |
| 2022-09-15 19:00:11September 15, 2022 | Windermere Prep Lakers | 42 - 21 | Thornton(CO) Riverdale Ridge | 2022 | N/A |
