| 2022-09-12 19:00:12September 12, 2022 | Christ's Church Academy Eagles | 24 - 34 | Beachside Barracudas | 2022 | N/A |
| 2022-09-10 19:00:54September 10, 2022 | St. Edward's Pirates | 42 - 16 | Berean Christian Bulldogs | 2022 | N/A |
| 2022-09-10 19:00:26September 10, 2022 | North Charleston(SC) Fort Dorchester Patriots | 0 - 31 | CAI Knights | 2022 | N/A |
| 2022-09-10 18:00:49September 10, 2022 | FSDB Dragons | 0 - 66 | Frederick(MD) MSD Orioles | 2022 | N/A |
| 2022-09-10 17:00:03September 10, 2022 | Douglas(GA) Coffee County Trojans | 34 - 14 |  St. Augustine Yellow Jackets | 2022 | N/A |
| 2022-09-10 10:00:14September 10, 2022 | Tohopekaliga Tigers  | 48 - 0 | Ambassadors Christian Academy Stallions | 2022 | N/A |
| 2022-09-10 10:00:13September 10, 2022 | Oasis Sharks | 0 - 21 | Fort Myers Canterbury Cougars | 2022 | N/A |
| 2022-09-10 09:30:15September 10, 2022 | Clay County Blue Devils | 30 - 35 | Orange Park Raiders | 2022 | N/A |
| 2022-09-09 19:30:33September 9, 2022 | Lafayette Hornets | 34 - 20 | Hamilton County Trojans | 2022 | N/A |
| 2022-09-09 19:30:23September 9, 2022 | Salt Lake City(UT) East Leopards | 13 - 63 | IMG Academy National Ascenders | 2022 | N/A |
| 2022-09-09 19:30:15September 9, 2022 | Seven Rivers Christian Warriors | 21 - 48 | Oak Hall Eagles | 2022 | N/A |
| 2022-09-09 19:00:59September 9, 2022 | Dunnellon Tigers | 20 - 21 | Vanguard Knights | 2022 | N/A |
| 2022-09-09 19:00:59September 9, 2022 | Wekiva Mustangs  | 27 - 30 | Lake Minneola Hawks | 2022 | N/A |
| 2022-09-09 19:00:59September 9, 2022 | Apopka Blue Darters  | 7 - 6 | Dr. Phillips Panthers | 2022 | N/A |
| 2022-09-09 19:00:58September 9, 2022 | Colonial Grenadiers | 0 - 48 |  Horizon Hawks | 2022 | N/A |
| 2022-09-09 19:00:58September 9, 2022 | Oakleaf Knights | 35 - 14 | TDH Christian Academy Eagles | 2022 | N/A |
| 2022-09-09 19:00:58September 9, 2022 | West Orange Warriors | 14 - 26 |  Edgewater Eagles | 2022 | N/A |
| 2022-09-09 19:00:58September 9, 2022 | Chipley Tigers | 18 - 0 | Holmes County Blue Devils | 2022 | N/A |
| 2022-09-09 19:00:57September 9, 2022 | West Centennial Eagles | 30 - 0 |  Heritage Panthers | 2022 | N/A |
| 2022-09-09 19:00:57September 9, 2022 | Poinciana Eagles  | 34 - 14 | LaBelle Cowboys | 2022 | N/A |
| 2022-09-09 19:00:56September 9, 2022 | Bradenton Christian Panthers | 21 - 37 | Southwest Florida Christian Academy King's | 2022 | N/A |
| 2022-09-09 19:00:55September 9, 2022 | Lake Weir Hurricanes  | 0 - 40 | Ridgeview Panthers | 2022 | N/A |
| 2022-09-09 19:00:55September 9, 2022 | Crystal River Pirates | 30 - 0 | East Ridge Knights | 2022 | N/A |
| 2022-09-09 19:00:55September 9, 2022 | All Saints Academy Saints | 38 - 0 | Lake Mary Prep Griffins | 2022 | N/A |
| 2022-09-09 19:00:53September 9, 2022 | City of Life Christian Warriors | 14 - 38 | Oasis Christian Lions | 2022 | N/A |
| 2022-09-09 19:00:50September 9, 2022 | Discovery Spartans | 21 - 42 | Umatilla Bulldogs | 2022 | N/A |
| 2022-09-09 19:00:50September 9, 2022 | West Port Wolf Pack | 7 - 40 |  Berkeley Prep Buccaneers | 2022 | N/A |
| 2022-09-09 19:00:49September 9, 2022 | Columbia Tigers | 21 - 16 | DeLand Bulldogs | 2022 | N/A |
| 2022-09-09 19:00:49September 9, 2022 | St. Thomas Aquinas Raiders  | 42 - 14 |  Cocoa Tigers | 2022 | N/A |
| 2022-09-09 19:00:49September 9, 2022 | Rockledge Raiders | 41 - 0 | Viera Hawks | 2022 | N/A |
| 2022-09-09 19:00:46September 9, 2022 | Oviedo Lions | 7 - 13 |  Lake Mary Rams | 2022 | N/A |
| 2022-09-09 19:00:45September 9, 2022 | Key West Conchs | 20 - 40 | TRU Prep Academy Saints | 2022 | N/A |
| 2022-09-09 19:00:44September 9, 2022 | Mainland Buccaneers  | 3 - 17 | Bartram Trail Bears | 2022 | N/A |
| 2022-09-09 19:00:44September 9, 2022 | Palatka Panthers | 33 - 13 | Santa Fe Raiders | 2022 | N/A |
| 2022-09-09 19:00:44September 9, 2022 | Haines City Hornets | 38 - 7 | Celebration Storm | 2022 | N/A |
| 2022-09-09 19:00:43September 9, 2022 | Satellite Scorpions | 0 - 24 | Melbourne Bulldogs | 2022 | N/A |
| 2022-09-09 19:00:43September 9, 2022 | Crescent City Raiders | 7 - 22 |  Interlachen Rams | 2022 | N/A |
| 2022-09-09 19:00:43September 9, 2022 | The Master's Academy Eagles | 43 - 28 | St. Petersburg Catholic Barons | 2022 | N/A |
| 2022-09-09 19:00:42September 9, 2022 | Davenport Broncos | 20 - 30 |  Lyman Greyhounds | 2022 | N/A |
| 2022-09-09 19:00:42September 9, 2022 | Mount Dora Hurricanes | 33 - 32 |  Leesburg Yellow Jackets | 2022 | N/A |
| 2022-09-09 19:00:41September 9, 2022 | Bradford Tornadoes  | 21 - 0 | Middleburg Broncos | 2022 | N/A |
| 2022-09-09 19:00:41September 9, 2022 | North Marion Colts | 26 - 13 | Belleview Rattlers | 2022 | N/A |
| 2022-09-09 19:00:40September 9, 2022 | Sanford Seminole Seminoles | 41 - 22 | Treasure Coast Titans | 2022 | N/A |
| 2022-09-09 19:00:40September 9, 2022 | Santa Fe Catholic Hawks | 40 - 0 | First Academy Eagles | 2022 | N/A |
| 2022-09-09 19:00:39September 9, 2022 | Orange City University Titans  | 28 - 9 |  Seabreeze Sandcrabs | 2022 | N/A |
| 2022-09-09 19:00:38September 9, 2022 | Evans Trojans  | 0 - 34 |  Ocoee Knights | 2022 | N/A |
| 2022-09-09 19:00:38September 9, 2022 | Bell Creek Academy Panthers | 0 - 35 | Indian Rocks Christian Golden Eagles | 2022 | N/A |
| 2022-09-09 19:00:37September 9, 2022 | Countryside Christian Minutemen | 19:00:37Postponed |  Merritt Island Christian Cougars | 2022 | N/A |
| 2022-09-09 19:00:37September 9, 2022 | Four Corners Charter Coyotes | 18 - 35 | Sarasota Christian Blazers | 2022 | N/A |
| 2022-09-09 19:00:36September 9, 2022 | Liberty Chargers | 0 - 37 | St. Cloud Bulldogs | 2022 | N/A |
| 2022-09-09 19:00:36September 9, 2022 | Bay Tornadoes | 35 - 6 | Port St. Joe Tiger Sharks | 2022 | N/A |
| 2022-09-09 19:00:35September 9, 2022 | Matanzas Pirates | 7 - 26 | Deltona Wolves | 2022 | N/A |
| 2022-09-09 19:00:35September 9, 2022 | Fort Pierce Central Cobras | 6 - 13 | Bayside Bears | 2022 | N/A |
| 2022-09-09 19:00:35September 9, 2022 | Classical Prep Lions | 19:00:357:00 pm | USCEDEA Stars | 2022 | N/A |
| 2022-09-09 19:00:34September 9, 2022 | Orangewood Christian Rams | 0 - 50 | Orlando Christian Prep Warriors | 2022 | N/A |
| 2022-09-09 19:00:33September 9, 2022 | Lake Nona Lions  | 14 - 20 | Olympia Titans | 2022 | N/A |
| 2022-09-09 19:00:33September 9, 2022 | Marianna Bulldogs | 7 - 20 | Blountstown Tigers | 2022 | N/A |
| 2022-09-09 19:00:31September 9, 2022 | Spruce Creek Hawks | WIN - FORFEIT |  FPC Bulldogs | 2022 | N/A |
| 2022-09-09 19:00:31September 9, 2022 | Father Lopez Green Wave | 12 - 35 |  Port Orange Atlantic Sharks | 2022 | N/A |
| 2022-09-09 19:00:31September 9, 2022 | Lake Buena Vista Vipers | 13 - 41 | Orlando Freedom Patriots | 2022 | N/A |
| 2022-09-09 19:00:31September 9, 2022 | Baker Gators | 21 - 20 | Bozeman Bucks | 2022 | N/A |
| 2022-09-09 19:00:31September 9, 2022 | Graceville Tigers | 8 - 32 | Sneads Pirates | 2022 | N/A |
| 2022-09-09 19:00:28September 9, 2022 | St. Joseph Academy Flashes | 8 - 6 | Halifax Academy Knights | 2022 | N/A |
| 2022-09-09 19:00:27September 9, 2022 | Fort White Indians | 28 - 0 | Keystone Heights Indians | 2022 | N/A |
| 2022-09-09 19:00:27September 9, 2022 | Trinity Prep Saints | 0 - 56 | Foundation Academy Lions | 2022 | N/A |
| 2022-09-09 19:00:26September 9, 2022 | Winter Springs Bears | 0 - 48 |  Hagerty Huskies | 2022 | N/A |
| 2022-09-09 19:00:25September 9, 2022 | Timber Creek Wolves | 31 - 14 | East River Falcons | 2022 | N/A |
| 2022-09-09 19:00:25September 9, 2022 | Nease Panthers | 14 - 19 | Fleming Island Golden Eagles | 2022 | N/A |
| 2022-09-09 19:00:25September 9, 2022 | Palmetto Ridge Bears | 0 - 56 |  Lake Brantley Patriots | 2022 | N/A |
| 2022-09-09 19:00:23September 9, 2022 | Terry Parker Braves | 18 - 36 |  Hawthorne Hornets | 2022 | N/A |
| 2022-09-09 19:00:23September 9, 2022 | Saint Stephen's Episcopal Falcons | 22 - 26 | Out-Of-Door Academy Thunder | 2022 | N/A |
| 2022-09-09 19:00:22September 9, 2022 | Merritt Island Mustangs | 35 - 0 | Astronaut War Eagles | 2022 | N/A |
| 2022-09-09 19:00:22September 9, 2022 | Lakeside Christian Lions | 52 - 6 | The Classical Academy Patriots | 2022 | N/A |
| 2022-09-09 19:00:20September 9, 2022 | Saint Brendan Sabres | 13 - 21 | Westminster Academy Lions | 2022 | N/A |
| 2022-09-09 19:00:19September 9, 2022 | Oak Ridge Pioneers | 7 - 20 | Orlando University Cougars | 2022 | N/A |
| 2022-09-09 19:00:19September 9, 2022 | Eastside Rams | 19:00:19Canceled | Buchholz Bobcats | 2022 | N/A |
| 2022-09-09 19:00:16September 9, 2022 | Eustis Panthers | 34 - 0 | Tavares Bulldogs | 2022 | N/A |
| 2022-09-09 19:00:16September 9, 2022 | Mulberry Panthers | 8 - 28 | The First Academy Royals | 2022 | N/A |
| 2022-09-09 19:00:12September 9, 2022 | Forest Wildcats  | 22 - 36 | First Coast Buccaneers | 2022 | N/A |
| 2022-09-09 19:00:11September 9, 2022 | Lake Howell Silver Hawks | 34 - 0 | Faith Christian Academy Lions | 2022 | N/A |
| 2022-09-09 19:00:10September 9, 2022 | Riverside Christian School Wranglers | FORFEIT - WIN | Bishop Snyder Cardinals | 2022 | N/A |
| 2022-09-09 19:00:10September 9, 2022 | Freeport Bulldogs | 20 - 13 | Liberty County Bulldogs | 2022 | N/A |
| 2022-09-09 19:00:09September 9, 2022 | Eau Gallie Commodores | 20 - 17 |  Bishop Moore Hornets | 2022 | N/A |
| 2022-09-09 19:00:08September 9, 2022 | Cornerstone Charter Ducks | 7 - 13 | Legacy Charter Eagles | 2022 | N/A |
| 2022-09-09 19:00:08September 9, 2022 | Vernon Yellow Jackets | 6 - 24 | Wewahitchka Gators | 2022 | N/A |
| 2022-09-09 19:00:05September 9, 2022 | IMG Academy Varsity White Ascenders | 44 - 0 | Southeast Seminoles | 2022 | N/A |
| 2022-09-09 19:00:05September 9, 2022 | Melbourne Central Catholic Hustlers | 0 - 63 | Windermere Prep Lakers | 2022 | N/A |
| 2022-09-09 19:00:04September 9, 2022 | Menendez Falcons  | 40 - 0 |  Pine Ridge Panthers | 2022 | N/A |
| 2022-09-09 19:00:04September 9, 2022 | Harmony Longhorns | 13 - 12 | Palm Bay Pirates | 2022 | N/A |
| 2022-09-09 19:00:04September 9, 2022 | Evangelical Christian Sentinels | 34 - 0 | Gateway Charter Griffins | 2022 | N/A |
| 2022-09-09 19:00:02September 9, 2022 | Winter Park Wildcats | 38 - 3 | Boone Braves | 2022 | N/A |
| 2022-09-09 19:00:01September 9, 2022 | Trenton Tigers | 6 - 65 | Newberry Panthers | 2022 | N/A |
| 2022-09-09 19:00:01September 9, 2022 | Tocoi Creek Toros  | 13 - 25 | Bishop Kenny Crusaders | 2022 | N/A |
| 2022-09-09 19:00:01September 9, 2022 | South Lake Eagles  | 0 - 42 | Savannah(GA) New Hampstead Phoenix | 2022 | N/A |
| 2022-09-09 19:00:01September 9, 2022 | Orlando Cypress Creek Bears | 27 - 0 |  Windermere Wolverines | 2022 | N/A |
| 2022-09-09 19:00:00September 9, 2022 | Taylor Wildcats | 0 - 49 | Cocoa Beach Minutemen | 2022 | N/A |
| 2022-09-09 19:00:00September 9, 2022 | Aucilla Christian Warriors | 46 - 0 | St. Francis Catholic Wolves | 2022 | N/A |
| 2022-09-09 18:30:50September 9, 2022 | Paxon Golden Eagles | 14 - 41 | Hilliard Flashes | 2022 | N/A |
| 2022-09-09 18:30:25September 9, 2022 | Ribault Trojans | 38 - 7 | Stanton Prep Blue Devils | 2022 | N/A |
| 2022-09-09 17:30:42September 9, 2022 | Real Life Christian Raptors | 28 - 45 | St. Johns Country Day Spartans | 2022 | N/A |
| 2022-09-09 16:00:44September 9, 2022 | Duval Charter School Panthers | 32 - 0 | Academy At The Lakes Wildcats | 2022 | N/A |
| 2022-09-08 20:00:44September 8, 2022 | Brunswick(GA) Glynn Academy Red Terrors | 20 - 21 | Creekside Knights | 2022 | N/A |
| 2022-09-08 19:00:43September 8, 2022 | IMG Academy Varsity Blue Ascenders | 28 - 10 | North Port Bobcats | 2022 | N/A |
| 2022-09-08 19:00:40September 8, 2022 | John Carroll Golden Rams | 19:00:40Canceled | Tradition Prep Pirates | 2022 | N/A |
| 2022-09-08 19:00:35September 8, 2022 | Gainesville Purple Hurricanes | 3 - 48 |  Trinity Catholic Celtics | 2022 | N/A |
| 2022-09-08 19:00:32September 8, 2022 | Donahue Academy Shamrocks | 19:00:32Canceled | Shorecrest Prep Chargers | 2022 | N/A |
| 2022-09-08 19:00:25September 8, 2022 | Palm Beach Christian Saints | 58 - 0 | Boca Raton Christian Blazers | 2022 | N/A |
| 2022-09-08 18:30:35September 8, 2022 | Jupiter Christian School Eagles | 21 - 30 | Glades Day Gators | 2022 | N/A |
