| 2022-09-06 19:00:13September 6, 2022 | Tohopekaliga  | 19:00:13Canceled | Kissimmee Gateway Panthers | 2022 | N/A |
| 2022-09-03 19:00:46September 3, 2022 | Cincinnati(OH) Cincinnati Hills Christian Eagles | 28 - 14 | The Master's Academy Eagles | 2022 | N/A |
| 2022-09-03 15:00:49September 3, 2022 | St. Louis(MO) De Smet Jesuit Spartans | 6 - 50 | IMG Academy National Ascenders | 2022 | N/A |
| 2022-09-03 15:00:37September 3, 2022 | Duncanville(TX) | 44 - 21 |  Jones | 2022 | N/A |
| 2022-09-02 19:30:28September 2, 2022 | Suwanee(GA) North Gwinnett Bulldogs | 19 - 31 |  Winter Park | 2022 | N/A |
| 2022-09-02 19:30:20September 2, 2022 | Hamilton County Trojans | 0 - 41 | Suwannee Bulldogs | 2022 | N/A |
| 2022-09-02 19:30:11September 2, 2022 | Taylor County Bulldogs | 13 - 12 | Lafayette Hornets | 2022 | N/A |
| 2022-09-02 19:00:59September 2, 2022 | Viera  | 7 - 21 |  Satellite | 2022 | N/A |
| 2022-09-02 19:00:59September 2, 2022 | St. Francis Catholic Wolves | 8 - 43 | Santa Fe Catholic Hawks | 2022 | N/A |
| 2022-09-02 19:00:59September 2, 2022 | DeLand  | 40 - 22 | Centennial | 2022 | N/A |
| 2022-09-02 19:00:58September 2, 2022 | Trenton Tigers | 0 - 46 | Dixie County Bears | 2022 | N/A |
| 2022-09-02 19:00:58September 2, 2022 | Bradford Tornadoes  | 35 - 0 | Baldwin Indians | 2022 | N/A |
| 2022-09-02 19:00:57September 2, 2022 | South Sumter Raiders | 41 - 0 |  South Lake | 2022 | N/A |
| 2022-09-02 19:00:57September 2, 2022 | North Bay Haven Buccaneers | 0 - 39 | Holmes County Blue Devils | 2022 | N/A |
| 2022-09-02 19:00:56September 2, 2022 | Wekiva  | 14 - 15 |  Ocoee | 2022 | N/A |
| 2022-09-02 19:00:56September 2, 2022 | Oak Hall Eagles | 49 - 12 | Bishop Snyder Cardinals | 2022 | N/A |
| 2022-09-02 19:00:56September 2, 2022 | CAI Knights | 26 - 0 | Miami Palmetto Panthers | 2022 | N/A |
| 2022-09-02 19:00:55September 2, 2022 | Ridgeview  | 22 - 33 |  Clay County | 2022 | N/A |
| 2022-09-02 19:00:55September 2, 2022 | West Orange  | 13 - 6 |  Apopka | 2022 | N/A |
| 2022-09-02 19:00:55September 2, 2022 | Lighthouse PCA Stingrays | 0 - 37 | Northview Chiefs | 2022 | N/A |
| 2022-09-02 19:00:54September 2, 2022 | Santa Fe Raiders | 14 - 17 | Lakeland(GA) Lanier County Bulldogs | 2022 | N/A |
| 2022-09-02 19:00:53September 2, 2022 | Horizon  | 26 - 3 |  Lake Howell | 2022 | N/A |
| 2022-09-02 19:00:52September 2, 2022 | Cornerstone Charter Ducks | 9 - 14 | Seven Rivers Christian Warriors | 2022 | N/A |
| 2022-09-02 19:00:51September 2, 2022 | Sarasota Christian Blazers | 12 - 30 | St. Petersburg Canterbury Crusaders | 2022 | N/A |
| 2022-09-02 19:00:51September 2, 2022 | North Port Bobcats | 32 - 47 | Gateway Charter Griffins | 2022 | N/A |
| 2022-09-02 19:00:50September 2, 2022 | Brooksville Central Bears | 47 - 13 |  Lake Weir Hurricanes | 2022 | N/A |
| 2022-09-02 19:00:50September 2, 2022 | Palm Bay  | 21 - 8 |  Heritage | 2022 | N/A |
| 2022-09-02 19:00:49September 2, 2022 | Dunnellon  | 0 - 35 |  North Marion | 2022 | N/A |
| 2022-09-02 19:00:48September 2, 2022 | Legacy Charter Eagles | 40 - 0 | Taylor Wildcats | 2022 | N/A |
| 2022-09-02 19:00:47September 2, 2022 | Boone  | 14 - 6 |  Evans | 2022 | N/A |
| 2022-09-02 19:00:46September 2, 2022 | Pine Ridge  | 7 - 47 |  St. Cloud | 2022 | N/A |
| 2022-09-02 19:00:46September 2, 2022 | Leesburg  | 6 - 30 | Wildwood Wildcats | 2022 | N/A |
| 2022-09-02 19:00:45September 2, 2022 | Mount Dora Christian Bulldogs | WIN - FORFEIT | CFCA Eagles | 2022 | N/A |
| 2022-09-02 19:00:45September 2, 2022 | Westminster Academy Lions | 23 - 0 | Bradenton Christian Panthers | 2022 | N/A |
| 2022-09-02 19:00:44September 2, 2022 | Deltona  | 45 - 7 |  Mount Dora | 2022 | N/A |
| 2022-09-02 19:00:44September 2, 2022 | Bishop Moore  | 49 - 17 |  Gainesville | 2022 | N/A |
| 2022-09-02 19:00:43September 2, 2022 | Eagle's View Academy Warriors | 8 - 28 | Harvest Community School Warriors | 2022 | N/A |
| 2022-09-02 19:00:42September 2, 2022 | Olympia  | 41 - 7 | Oak Ridge Pioneers | 2022 | N/A |
| 2022-09-02 19:00:41September 2, 2022 | IMG Academy Varsity White Ascenders | 49 - 20 | Orlando Christian Prep Warriors | 2022 | N/A |
| 2022-09-02 19:00:41September 2, 2022 | East River Falcons | 17 - 3 | Orlando University Cougars | 2022 | N/A |
| 2022-09-02 19:00:38September 2, 2022 | Trinity Prep Saints | 6 - 55 | Faith Christian Academy Lions | 2022 | N/A |
| 2022-09-02 19:00:37September 2, 2022 | Niceville Eagles | 15 - 7 |  Vanguard | 2022 | N/A |
| 2022-09-02 19:00:37September 2, 2022 | Ponte Vedra  | 13 - 24 | Florida High Seminoles | 2022 | N/A |
| 2022-09-02 19:00:37September 2, 2022 | Melbourne Central Catholic Hustlers | 0 - 46 | Space Coast Vipers | 2022 | N/A |
| 2022-09-02 19:00:37September 2, 2022 | Foundation Academy Lions | 7 - 43 | Lake Highland Prep Highlanders | 2022 | N/A |
| 2022-09-02 19:00:36September 2, 2022 | Celebration  | 0 - 36 |  Harmony | 2022 | N/A |
| 2022-09-02 19:00:36September 2, 2022 | Lake Buena Vista Vipers | 13 - 28 | Orlando Cypress Creek Bears | 2022 | N/A |
| 2022-09-02 19:00:35September 2, 2022 | Interlachen Rams  | 14 - 8 | Providence School Stallions | 2022 | N/A |
| 2022-09-02 19:00:35September 2, 2022 | Baker County Wildcats | 25 - 20 |  Oakleaf | 2022 | N/A |
| 2022-09-02 19:00:34September 2, 2022 | Bishop Kenny Crusaders | 45 - 25 |  Middleburg | 2022 | N/A |
| 2022-09-02 19:00:34September 2, 2022 | Wewahitchka Gators | 38 - 8 | Bell Bulldogs | 2022 | N/A |
| 2022-09-02 19:00:32September 2, 2022 | Creekside  | 62 - 41 |  Nease | 2022 | N/A |
| 2022-09-02 19:00:32September 2, 2022 | Calvary Chapel Eagles | WIN - FORFEIT | Master's Academy Patriots | 2022 | N/A |
| 2022-09-02 19:00:31September 2, 2022 | Loveland(CO) Resurrection Christian Cougars | 36 - 0 | Orangewood Christian Rams | 2022 | N/A |
| 2022-09-02 19:00:30September 2, 2022 | Lake Mary Prep Griffins | 0 - 35 |  Merritt Island Christian Cougars | 2022 | N/A |
| 2022-09-02 19:00:28September 2, 2022 | Belleview  | 16 - 6 | Crystal River Pirates | 2022 | N/A |
| 2022-09-02 19:00:28September 2, 2022 | Rickards Raiders | 20 - 51 |  Fleming Island | 2022 | N/A |
| 2022-09-02 19:00:27September 2, 2022 | Matanzas  | 14 - 47 |  Tocoi Creek | 2022 | N/A |
| 2022-09-02 19:00:27September 2, 2022 | Rockledge  | 45 - 7 | Doral Academy Firebirds | 2022 | N/A |
| 2022-09-02 19:00:27September 2, 2022 | Deltona Trinity Christian Academy Eagles | 22 - 18 | First Academy Eagles | 2022 | N/A |
| 2022-09-02 19:00:26September 2, 2022 | Titusville  | 21 - 26 | Yulee Hornets | 2022 | N/A |
| 2022-09-02 19:00:26September 2, 2022 | Chiefland Indians | 45 - 0 | West Oaks Academy Flames | 2022 | N/A |
| 2022-09-02 19:00:24September 2, 2022 | St. Augustine  | 48 - 12 | Gibbs Gladiators | 2022 | N/A |
| 2022-09-02 19:00:24September 2, 2022 | Colonial Grenadiers | 6 - 41 | Arvada(CO) Ralston Valley Mustangs | 2022 | N/A |
| 2022-09-02 19:00:24September 2, 2022 | The First Academy Royals | 24 - 10 | Seffner Christian Crusaders | 2022 | N/A |
| 2022-09-02 19:00:23September 2, 2022 | Lake Brantley  | 49 - 12 |  Lyman | 2022 | N/A |
| 2022-09-02 19:00:23September 2, 2022 | Father Lopez Green Wave | 39 - 0 | St. Joseph Academy Flashes | 2022 | N/A |
| 2022-09-02 19:00:23September 2, 2022 | Lecanto Panthers | 7 - 0 |  Tavares | 2022 | N/A |
| 2022-09-02 19:00:23September 2, 2022 | Inlet Grove Hurricanes | 37 - 14 | Jupiter Christian School Eagles | 2022 | N/A |
| 2022-09-02 19:00:22September 2, 2022 | Melbourne  | 29 - 12 |  Merritt Island | 2022 | N/A |
| 2022-09-02 19:00:22September 2, 2022 | Holy Trinity Tigers | 14 - 50 | Bayside Bears | 2022 | N/A |
| 2022-09-02 19:00:21September 2, 2022 | Orange Park  | 28 - 29 | Episcopal School Eagles | 2022 | N/A |
| 2022-09-02 19:00:20September 2, 2022 | Trinity Catholic Celtics  | 35 - 27 |  Clearwater Central Catholic Marauders | 2022 | N/A |
| 2022-09-02 19:00:19September 2, 2022 | Bell Creek Academy Panthers | 0 - 43 | Cambridge Christian Lancers | 2022 | N/A |
| 2022-09-02 19:00:19September 2, 2022 | Arnold Marlins | 49 - 72 | Sneads Pirates | 2022 | N/A |
| 2022-09-02 19:00:18September 2, 2022 | Edgewater  | 34 - 10 | Ramsey(NJ) Don Bosco Prep Ironmen | 2022 | N/A |
| 2022-09-02 19:00:18September 2, 2022 | Orlando Freedom  | 36 - 6 |  Windermere Wolverines | 2022 | N/A |
| 2022-09-02 19:00:17September 2, 2022 | Timber Creek  | 24 - 22 |  Dr. Phillips | 2022 | N/A |
| 2022-09-02 19:00:17September 2, 2022 | Cocoa Beach Minutemen | 56 - 0 | Berean Christian Bulldogs | 2022 | N/A |
| 2022-09-02 19:00:16September 2, 2022 | Seabreeze  | 27 - 38 |  Bartram Trail | 2022 | N/A |
| 2022-09-02 19:00:16September 2, 2022 | Shorecrest Prep Chargers | 35 - 0 | Lakeside Christian Lions | 2022 | N/A |
| 2022-09-02 19:00:15September 2, 2022 | Lake Mary  | 19 - 0 |  Spruce Creek | 2022 | N/A |
| 2022-09-02 19:00:14September 2, 2022 | Astronaut War Eagles | 0 - 42 | Sebastian River Sharks | 2022 | N/A |
| 2022-09-02 19:00:12September 2, 2022 | Orange City University  | 7 - 35 |  Oviedo | 2022 | N/A |
| 2022-09-02 19:00:12September 2, 2022 | West Port  | 30 - 0 |  Winter Springs | 2022 | N/A |
| 2022-09-02 19:00:12September 2, 2022 | Fort White Indians | 17 - 34 | Newberry Panthers | 2022 | N/A |
| 2022-09-02 19:00:12September 2, 2022 | Out-Of-Door Academy Thunder | 51 - 29 | Oasis Sharks | 2022 | N/A |
| 2022-09-02 19:00:11September 2, 2022 | Halifax Academy Knights | 6 - 44 | Cedar Creek Christian Saints | 2022 | N/A |
| 2022-09-02 19:00:11September 2, 2022 | Buchholz  | 45 - 6 | Sarasota Riverview Rams | 2022 | N/A |
| 2022-09-02 19:00:11September 2, 2022 | Liberty County Bulldogs | 7 - 14 | Bozeman Bucks | 2022 | N/A |
| 2022-09-02 19:00:11September 2, 2022 | Lakeland Christian Vikings | 19:00:11Canceled | American Collegiate Academy Rough Riders | 2022 | N/A |
| 2022-09-02 19:00:11September 2, 2022 | Ambassadors Christian Academy Stallions | FORFEIT - WIN | TRU Prep Academy Saints | 2022 | N/A |
| 2022-09-02 19:00:10September 2, 2022 | Palatka Panthers | 34 - 7 |  Port Orange Atlantic | 2022 | N/A |
| 2022-09-02 19:00:09September 2, 2022 | Kissimmee Osceola  | 27 - 28 |  Sanford Seminole | 2022 | N/A |
| 2022-09-02 19:00:07September 2, 2022 | Lake Nona  | 29 - 19 | Broomfield(CO) Legacy Lightning | 2022 | N/A |
| 2022-09-02 19:00:07September 2, 2022 | The Classical Academy Patriots | 22 - 54 | Oasis Christian Lions | 2022 | N/A |
| 2022-09-02 19:00:06September 2, 2022 | Zephyrhills Christian Warriors | 20 - 16 |  New Smyrna Beach | 2022 | N/A |
| 2022-09-02 19:00:06September 2, 2022 | Saint Stephen's Episcopal Falcons | 6 - 21 | Northside Christian Mustangs | 2022 | N/A |
| 2022-09-02 19:00:04September 2, 2022 | Beachside  | 17 - 13 | Fernandina Beach Pirates | 2022 | N/A |
| 2022-09-02 19:00:03September 2, 2022 | Windermere Prep Lakers | 35 - 19 | Lake Placid Green Dragons | 2022 | N/A |
| 2022-09-02 19:00:00September 2, 2022 | Peniel Academy Warriors | 19:00:007:00 pm | Village View Christian Eagles | 2022 | N/A |
| 2022-09-02 18:30:47September 2, 2022 | Wolfson Wolfpack | 28 - 21 | Paxon Golden Eagles | 2022 | N/A |
| 2022-09-02 18:30:38September 2, 2022 | Old Plank Christian Defenders | 47 - 7 | Ocala Christian Crusaders | 2022 | N/A |
| 2022-09-02 18:30:24September 2, 2022 | Englewood Rams | 14 - 7 |  Menendez | 2022 | N/A |
| 2022-09-02 18:30:04September 2, 2022 | Stanton Prep Blue Devils | 8 - 45 | NFEI Eagles | 2022 | N/A |
| 2022-09-02 17:00:18September 2, 2022 | Eastland Christian Hurricanes | 49 - 6 | City of Life Christian Warriors | 2022 | N/A |
| 2022-09-02 16:00:52September 2, 2022 | Duval Charter School Panthers | 12 - 2 | St. Johns Country Day Spartans | 2022 | N/A |
| 2022-09-02 16:00:02September 2, 2022 | Boca Raton Christian Blazers | 17 - 0 | Somerset Academy Key Lions | 2022 | N/A |
| 2022-09-01 19:00:43September 1, 2022 | St. Edward's Pirates | 40 - 14 | WPB SLAM Cobras | 2022 | N/A |
| 2022-09-01 19:00:39September 1, 2022 | FSDB Dragons | 22 - 13 | St. John Lutheran Saints | 2022 | N/A |
| 2022-09-01 19:00:39September 1, 2022 | Eastside  | 26 - 0 | Keystone Heights Indians | 2022 | N/A |
| 2022-09-01 19:00:36September 1, 2022 | IMG Academy Varsity Blue Ascenders | 43 - 36 | Lemon Bay Manta Rays | 2022 | N/A |
| 2022-09-01 19:00:29September 1, 2022 | Umatilla Bulldogs | 13 - 27 | Crescent City Raiders | 2022 | N/A |
| 2022-09-01 19:00:26September 1, 2022 | Lake Minneola  | 42 - 0 |  Eustis | 2022 | N/A |
| 2022-09-01 19:00:26September 1, 2022 | Discovery Spartans | 0 - 50 |  Poinciana Eagles | 2022 | N/A |
| 2022-09-01 19:00:20September 1, 2022 | Fort Meade Miners | 21 - 8 | A'kelynn's Angels Christian Academy Wildcats | 2022 | N/A |
| 2022-09-01 19:00:15September 1, 2022 | Impact Christian Academy Lions | 38 - 22 | Riverside Christian School Wranglers | 2022 | N/A |
| 2022-09-01 19:00:15September 1, 2022 | Rutherford Rams | 6 - 33 | Blountstown Tigers | 2022 | N/A |
| 2022-09-01 19:00:10September 1, 2022 | Fort Myers Canterbury Cougars | 10 - 6 | Southwest Florida Christian Academy King's | 2022 | N/A |
| 2022-09-01 19:00:09September 1, 2022 | Liberty Chargers | 0 - 55 |  Eau Gallie | 2022 | N/A |
| 2022-09-01 18:00:57September 1, 2022 | Surge Academy Lions | FORFEIT - WIN | Palm Beach Christian Saints | 2022 | N/A |
