| 2022-10-25 19:00:42October 25, 2022 | Boone  | 48 - 21 |  Lake Nona | 2022 | N/A |
| 2022-10-25 19:00:22October 25, 2022 | Williston Red Devils | 48 - 0 | Hamilton County Trojans | 2022 | N/A |
| 2022-10-24 19:00:57October 24, 2022 | Celebration  | 21 - 20 |  Tohopekaliga | 2022 | N/A |
| 2022-10-24 19:00:48October 24, 2022 | Mainland  | 66 - 0 |  Pine Ridge | 2022 | N/A |
| 2022-10-24 19:00:45October 24, 2022 | Foundation Christian Panthers | 0 - 46 | Countryside Christian Minutemen | 2022 | N/A |
| 2022-10-24 19:00:33October 24, 2022 | City of Life Christian Warriors | 6 - 57 | Lake Mary Prep Griffins | 2022 | N/A |
| 2022-10-24 19:00:29October 24, 2022 | Academy At The Lakes Wildcats | 12 - 49 | St. Petersburg Canterbury Crusaders | 2022 | N/A |
| 2022-10-24 19:00:21October 24, 2022 | North Port Bobcats | 19:00:21Canceled |  Poinciana | 2022 | N/A |
| 2022-10-24 19:00:01October 24, 2022 | Olympia  | 48 - 10 |  Windermere | 2022 | N/A |
| 2022-10-24 18:30:17October 24, 2022 | Space Coast Vipers | 27 - 50 |  Holy Trinity | 2022 | N/A |
| 2022-10-24 18:00:56October 24, 2022 | Merritt Island Christian Cougars  | 12 - 38 | Master's Academy Patriots | 2022 | N/A |
| 2022-10-21 19:30:55October 21, 2022 | Seven Rivers Christian Warriors | 34 - 14 | Bishop Snyder Cardinals | 2022 | N/A |
| 2022-10-21 19:30:36October 21, 2022 | Lafayette  | 42 - 0 | Trenton Tigers | 2022 | N/A |
| 2022-10-21 19:30:31October 21, 2022 | Fleming Island  | 35 - 38 |  Creekside | 2022 | N/A |
| 2022-10-21 19:30:28October 21, 2022 | Hamilton County Trojans | 38 - 42 | NFEI Eagles | 2022 | N/A |
| 2022-10-21 19:00:59October 21, 2022 | Wekiva  | 7 - 21 |  Jones | 2022 | N/A |
| 2022-10-21 19:00:59October 21, 2022 | Space Coast Vipers | 0 - 44 |  Palm Bay | 2022 | N/A |
| 2022-10-21 19:00:58October 21, 2022 | Leesburg  | 12 - 48 |  Eustis | 2022 | N/A |
| 2022-10-21 19:00:56October 21, 2022 | Cornerstone Charter Ducks | 29 - 0 | Keswick Christian Crusaders | 2022 | N/A |
| 2022-10-21 19:00:55October 21, 2022 | Eagle's View Academy Warriors | 12 - 7 | Faith Christian Academy Lions | 2022 | N/A |
| 2022-10-21 19:00:52October 21, 2022 | Bartram Trail  | 21 - 6 |  Buchholz | 2022 | N/A |
| 2022-10-21 19:00:52October 21, 2022 | P.K. Yonge  | 14 - 42 |  Newberry | 2022 | N/A |
| 2022-10-21 19:00:51October 21, 2022 | Jupiter Christian School Eagles | 56 - 0 | Tradition Prep Pirates | 2022 | N/A |
| 2022-10-21 19:00:50October 21, 2022 | Walton Braves | 28 - 19 | Blountstown Tigers | 2022 | N/A |
| 2022-10-21 19:00:49October 21, 2022 | Sneads Pirates | 41 - 13 | Franklin County Seahawks | 2022 | N/A |
| 2022-10-21 19:00:48October 21, 2022 | Union County Tigers | 42 - 14 |  Santa Fe | 2022 | N/A |
| 2022-10-21 19:00:48October 21, 2022 | Cocoa Beach Minutemen | 43 - 6 |  Melbourne Central Catholic | 2022 | N/A |
| 2022-10-21 19:00:48October 21, 2022 | Community School of Naples Seahawks | 33 - 32 | Gateway Charter Griffins | 2022 | N/A |
| 2022-10-21 19:00:47October 21, 2022 | Orlando Cypress Creek  | 0 - 41 | Boone | 2022 | N/A |
| 2022-10-21 19:00:47October 21, 2022 | All Saints Academy Saints | 52 - 0 | Foundation Christian Panthers | 2022 | N/A |
| 2022-10-21 19:00:47October 21, 2022 | Providence School Stallions | 40 - 8 | Harvest Community School Warriors | 2022 | N/A |
| 2022-10-21 19:00:46October 21, 2022 | Orangewood Christian Rams | 36 - 15 |  Father Lopez | 2022 | N/A |
| 2022-10-21 19:00:46October 21, 2022 | Bradenton Christian Panthers | 21 - 37 | Out-Of-Door Academy Thunder | 2022 | N/A |
| 2022-10-21 19:00:46October 21, 2022 | Four Corners Charter Coyotes | 41 - 14 | Academy At The Lakes Wildcats | 2022 | N/A |
| 2022-10-21 19:00:45October 21, 2022 | Holmes County Blue Devils | 46 - 0 | Liberty County Bulldogs | 2022 | N/A |
| 2022-10-21 19:00:45October 21, 2022 | Wolfson Wolfpack | 56 - 6 | Impact Christian Academy Lions | 2022 | N/A |
| 2022-10-21 19:00:43October 21, 2022 | Oviedo  | 43 - 13 |  Lyman | 2022 | N/A |
| 2022-10-21 19:00:42October 21, 2022 | Holy Trinity | 7 - 27 |  Titusville | 2022 | N/A |
| 2022-10-21 19:00:41October 21, 2022 | Ocala Christian Crusaders | 24 - 64 | Lakeside Christian Lions | 2022 | N/A |
| 2022-10-21 19:00:41October 21, 2022 | Lake Mary Prep Griffins | 19 - 6 | Duval Charter School Panthers | 2022 | N/A |
| 2022-10-21 19:00:40October 21, 2022 | Lake Buena Vista  | 47 - 49 | Poinciana | 2022 | N/A |
| 2022-10-21 19:00:40October 21, 2022 | Legacy Charter Eagles | 14 - 38 | Santa Fe Catholic Hawks | 2022 | N/A |
| 2022-10-21 19:00:40October 21, 2022 | St. Petersburg Canterbury Crusaders | 34 - 0 | Oasis Christian Lions | 2022 | N/A |
| 2022-10-21 19:00:39October 21, 2022 | Mount Dora Christian Bulldogs | 50 - 0 | Deltona Trinity Christian Academy Eagles | 2022 | N/A |
| 2022-10-21 19:00:39October 21, 2022 | Astronaut  | 0 - 56 |  Cocoa | 2022 | N/A |
| 2022-10-21 19:00:39October 21, 2022 | Real Life Christian Raptors | 14 - 19 | St. John Lutheran Saints | 2022 | N/A |
| 2022-10-21 19:00:38October 21, 2022 | Lakeland Dreadnaughts  | 44 - 6 | CAI Knights | 2022 | N/A |
| 2022-10-21 19:00:37October 21, 2022 | Forest  | 7 - 35 |  Lake Minneola | 2022 | N/A |
| 2022-10-21 19:00:37October 21, 2022 | Pensacola Fighting Tigers | 38 - 0 | Lighthouse PCA Stingrays | 2022 | N/A |
| 2022-10-21 19:00:37October 21, 2022 | Ridgeview  | 15 - 32 | Fort White Indians | 2022 | N/A |
| 2022-10-21 19:00:35October 21, 2022 | Hawthorne  | 13 - 0 |  North Marion | 2022 | N/A |
| 2022-10-21 19:00:35October 21, 2022 | South Walton Seahawks | 10 - 20 | Port St. Joe Tiger Sharks | 2022 | N/A |
| 2022-10-21 19:00:34October 21, 2022 | DeLand  | 50 - 0 |  Orange City University | 2022 | N/A |
| 2022-10-21 19:00:34October 21, 2022 | Liberty  | 0 - 69 | Lake Wales Highlanders | 2022 | N/A |
| 2022-10-21 19:00:34October 21, 2022 | Gainesville Christian Warriors  | 57 - 42 | Cornerstone Academy Cougars | 2022 | N/A |
| 2022-10-21 19:00:33October 21, 2022 | Clay County  | 28 - 23 |  Matanzas | 2022 | N/A |
| 2022-10-21 19:00:33October 21, 2022 | Oak Hall Eagles | 19:00:33Canceled | St. Francis Catholic Wolves | 2022 | N/A |
| 2022-10-21 19:00:33October 21, 2022 | Eau Gallie  | 15 - 9 | Bayside Bears | 2022 | N/A |
| 2022-10-21 19:00:32October 21, 2022 | Merritt Island  | 7 - 40 |  Rockledge | 2022 | N/A |
| 2022-10-21 19:00:32October 21, 2022 | The First Academy  | 20 - 7 |  Foundation Academy | 2022 | N/A |
| 2022-10-21 19:00:31October 21, 2022 | East Ridge  | 7 - 6 |  West Port | 2022 | N/A |
| 2022-10-21 19:00:31October 21, 2022 | West Orange  | 19 - 17 |  Dr. Phillips | 2022 | N/A |
| 2022-10-21 19:00:30October 21, 2022 | Kissimmee Osceola  | 33 - 6 | Mainland | 2022 | N/A |
| 2022-10-21 19:00:29October 21, 2022 | Cedar Creek Christian Saints | 28 - 49 | Branford Buccaneers | 2022 | N/A |
| 2022-10-21 19:00:28October 21, 2022 | Hagerty  | 31 - 7 |  Orlando University | 2022 | N/A |
| 2022-10-21 19:00:28October 21, 2022 | Orlando Freedom  | 18 - 38 | Olympia | 2022 | N/A |
| 2022-10-21 19:00:26October 21, 2022 | Heritage  | 42 - 9 |  Viera | 2022 | N/A |
| 2022-10-21 19:00:26October 21, 2022 | Tavares  | 20 - 44 |  Mount Dora | 2022 | N/A |
| 2022-10-21 19:00:25October 21, 2022 | Lake Howell  | 13 - 3 |  Winter Springs | 2022 | N/A |
| 2022-10-21 19:00:25October 21, 2022 | West Oaks Academy  | 0 - 58 |  Orlando Christian Prep | 2022 | N/A |
| 2022-10-21 19:00:24October 21, 2022 | Keystone Heights  | 38 - 0 |  Taylor | 2022 | N/A |
| 2022-10-21 19:00:24October 21, 2022 | Beachside  | 55 - 41 |  Crescent City | 2022 | N/A |
| 2022-10-21 19:00:23October 21, 2022 | Belleview  | 14 - 16 |  Eastside | 2022 | N/A |
| 2022-10-21 19:00:22October 21, 2022 | Fernandina Beach Pirates | 27 - 15 |  Palatka | 2022 | N/A |
| 2022-10-21 19:00:21October 21, 2022 | Shorecrest Prep Chargers | 60 - 0 | City of Life Christian Warriors | 2022 | N/A |
| 2022-10-21 19:00:19October 21, 2022 | Interlachen Rams  | 46 - 0 |  Halifax Academy | 2022 | N/A |
| 2022-10-21 19:00:18October 21, 2022 | South Lake  | 7 - 28 |  Seabreeze | 2022 | N/A |
| 2022-10-21 19:00:17October 21, 2022 | CFCA  | 45 - 7 | Bell Creek Academy Panthers | 2022 | N/A |
| 2022-10-21 19:00:17October 21, 2022 | New Smyrna Beach  | 0 - 13 |  Spruce Creek | 2022 | N/A |
| 2022-10-21 19:00:17October 21, 2022 | Lake Mary  | 17 - 21 |  Apopka | 2022 | N/A |
| 2022-10-21 19:00:15October 21, 2022 | St. Augustine  | 58 - 0 |  Gainesville | 2022 | N/A |
| 2022-10-21 19:00:15October 21, 2022 | Countryside Christian Minutemen | 7 - 48 | Donahue Academy Shamrocks | 2022 | N/A |
| 2022-10-21 19:00:13October 21, 2022 | Edgewater  | 54 - 0 |  Horizon | 2022 | N/A |
| 2022-10-21 19:00:13October 21, 2022 | Saint Andrew's Scots | 28 - 42 | Lake Highland Prep Highlanders | 2022 | N/A |
| 2022-10-21 19:00:13October 21, 2022 | Saint Stephen's Episcopal Falcons | 35 - 12 | Oasis Sharks | 2022 | N/A |
| 2022-10-21 19:00:13October 21, 2022 | Bozeman Bucks | 20 - 42 | Chipley Tigers | 2022 | N/A |
| 2022-10-21 19:00:12October 21, 2022 | Ocoee  | 63 - 0 | Windermere | 2022 | N/A |
| 2022-10-21 19:00:12October 21, 2022 | The Master's Academy Eagles | 52 - 0 | Trinity Prep Saints | 2022 | N/A |
| 2022-10-21 19:00:12October 21, 2022 | St. Johns Country Day Spartans | 0 - 14 | Calvary Chapel Eagles | 2022 | N/A |
| 2022-10-21 19:00:10October 21, 2022 | IMG Academy Varsity White Ascenders | 45 - 0 | Ambassadors Christian Academy Stallions | 2022 | N/A |
| 2022-10-21 19:00:09October 21, 2022 | TRU Prep Academy Saints | 42 - 0 | Roar Prep & Vocational Academy Lions | 2022 | N/A |
| 2022-10-21 19:00:08October 21, 2022 | Lake Region Thunder | 28 - 6 |  Kissimmee Gateway | 2022 | N/A |
| 2022-10-21 19:00:08October 21, 2022 | Windermere Prep Lakers | 3 - 41 | Hudson Cobras | 2022 | N/A |
| 2022-10-21 19:00:07October 21, 2022 | Bradford  | 44 - 0 |  Dunnellon | 2022 | N/A |
| 2022-10-21 19:00:06October 21, 2022 | Lake Nona | 44 - 8 |  Oak Ridge | 2022 | N/A |
| 2022-10-21 19:00:05October 21, 2022 | Celebration | 0 - 70 |  Flagler Palm Coast | 2022 | N/A |
| 2022-10-21 19:00:05October 21, 2022 | Tohopekaliga | 7 - 40 |  Harmony | 2022 | N/A |
| 2022-10-21 19:00:05October 21, 2022 | Pine Crest Panthers | 55 - 14 | Westminster Academy Lions | 2022 | N/A |
| 2022-10-21 19:00:04October 21, 2022 | Ponte Vedra  | 30 - 6 |  Orange Park | 2022 | N/A |
| 2022-10-21 19:00:03October 21, 2022 | Lake Weir  | 24 - 33 | Umatilla Bulldogs | 2022 | N/A |
| 2022-10-21 19:00:03October 21, 2022 | Sanford Seminole  | 37 - 7 |  Lake Brantley | 2022 | N/A |
| 2022-10-21 19:00:03October 21, 2022 | The Classical Academy Patriots | 16 - 36 | Master's Academy Patriots | 2022 | N/A |
| 2022-10-21 19:00:02October 21, 2022 | Oakleaf  | 27 - 21 |  Madison County Cowboys | 2022 | N/A |
| 2022-10-21 19:00:01October 21, 2022 | Colonial  | 0 - 42 |  Winter Park | 2022 | N/A |
| 2022-10-21 19:00:00October 21, 2022 | Fort Myers Canterbury Cougars | 23 - 27 | Evangelical Christian Sentinels | 2022 | N/A |
| 2022-10-21 18:30:52October 21, 2022 | Geneva Classical Academy Knights | 0 - 42 | Hernando Christian Lions | 2022 | N/A |
| 2022-10-21 18:30:46October 21, 2022 | Paxon Golden Eagles | 0 - 50 | First Coast Buccaneers | 2022 | N/A |
| 2022-10-21 18:30:03October 21, 2022 | Stanton Prep Blue Devils | 14 - 0 | St. Joseph Academy Flashes | 2022 | N/A |
| 2022-10-20 19:00:57October 20, 2022 | Chiles Timberwolves | 48 - 6 | American Collegiate Academy Rough Riders | 2022 | N/A |
| 2022-10-20 19:00:48October 20, 2022 | Merritt Island Christian Cougars | 49 - 14 | FSDB Dragons | 2022 | N/A |
| 2022-10-20 19:00:36October 20, 2022 | Berean Christian Bulldogs | 0 - 35 | Pompano Beach Golden Tornadoes | 2022 | N/A |
| 2022-10-20 19:00:30October 20, 2022 | St. Edward's Pirates | 0 - 42 | Palm Beach Christian Saints | 2022 | N/A |
