| 2022-11-01 19:00:21November 1, 2022 | DeLand  | 23 - 15 |  Spruce Creek | 2022 | N/A |
| 2022-11-01 19:00:02November 1, 2022 | The Villages Charter Buffalo | 22 - 29 |  Eustis | 2022 | N/A |
| 2022-11-01 19:00:02November 1, 2022 | Orlando University Cougars | 34 - 0 | Colonial Grenadiers | 2022 | N/A |
| 2022-11-01 19:00:00November 1, 2022 | Apopka  | 24 - 23 |  Sanford Seminole | 2022 | N/A |
| 2022-11-01 18:00:27November 1, 2022 | Holy Trinity Tigers | 54 - 12 | Halifax Academy Knights | 2022 | N/A |
| 2022-11-01 18:00:08November 1, 2022 | West Orange  | 41 - 17 |  Ocoee | 2022 | N/A |
| 2022-11-01 16:00:12November 1, 2022 | Trinity Prep Saints | 0 - 35 | Orangewood Christian Rams | 2022 | N/A |
| 2022-10-31 19:00:00October 31, 2022 | Hardee Wildcats | 14 - 49 |  Poinciana Eagles | 2022 | N/A |
| 2022-10-31 18:00:01October 31, 2022 | Orange City University  | 0 - 7 |  New Smyrna Beach | 2022 | N/A |
| 2022-10-28 19:30:43October 28, 2022 | Vanguard  | 28 - 21 | Carol City Chiefs | 2022 | N/A |
| 2022-10-28 19:30:42October 28, 2022 | San Antonio(TX) Cornerstone Christian Warriors | 61 - 0 | Impact Christian Academy Lions | 2022 | N/A |
| 2022-10-28 19:30:34October 28, 2022 | Jefferson County Tigers | 28 - 35 | Lafayette Hornets | 2022 | N/A |
| 2022-10-28 19:30:31October 28, 2022 | IMG Academy National Ascenders | 58 - 0 | Middletown(DE) Cavaliers | 2022 | N/A |
| 2022-10-28 19:00:59October 28, 2022 | St. Augustine  | 45 - 7 |  Clay County | 2022 | N/A |
| 2022-10-28 19:00:59October 28, 2022 | Astronaut War Eagles | 0 - 34 |  Titusville | 2022 | N/A |
| 2022-10-28 19:00:58October 28, 2022 | Harmony  | 3 - 35 |  Heritage | 2022 | N/A |
| 2022-10-28 19:00:58October 28, 2022 | The Classical Academy Patriots | 0 - 44 | Donahue Academy Shamrocks | 2022 | N/A |
| 2022-10-28 19:00:58October 28, 2022 | Calvary Chapel Eagles | 12 - 30 | Lake Mary Prep Griffins | 2022 | N/A |
| 2022-10-28 19:00:54October 28, 2022 | Palm Bay  | 0 - 35 |  Cocoa | 2022 | N/A |
| 2022-10-28 19:00:52October 28, 2022 | Davenport Broncos | 38 - 16 | Kissimmee Gateway Panthers | 2022 | N/A |
| 2022-10-28 19:00:51October 28, 2022 | Orangewood Christian Rams | 21 - 28 | Windermere Prep Lakers | 2022 | N/A |
| 2022-10-28 19:00:49October 28, 2022 | Merritt Island  | 14 - 22 |  Satellite | 2022 | N/A |
| 2022-10-28 19:00:49October 28, 2022 | Melbourne Central Catholic Hustlers | 0 - 35 | Holy Trinity Tigers | 2022 | N/A |
| 2022-10-28 19:00:48October 28, 2022 | Port Orange Atlantic  | 47 - 6 | Taylor Wildcats | 2022 | N/A |
| 2022-10-28 19:00:47October 28, 2022 | Bayside Bears | 8 - 16 | Jensen Beach Falcons | 2022 | N/A |
| 2022-10-28 19:00:46October 28, 2022 | West Port  | 6 - 34 |  Forest | 2022 | N/A |
| 2022-10-28 19:00:45October 28, 2022 | Venice Indians  | 41 - 9 | IMG Academy Varsity White Ascenders | 2022 | N/A |
| 2022-10-28 19:00:45October 28, 2022 | Nease  | 34 - 35 |  Ponte Vedra | 2022 | N/A |
| 2022-10-28 19:00:43October 28, 2022 | St. John Lutheran Saints | 6 - 20 | Ocala Christian Crusaders | 2022 | N/A |
| 2022-10-28 19:00:42October 28, 2022 | Matanzas  | 6 - 18 |  Menendez | 2022 | N/A |
| 2022-10-28 19:00:42October 28, 2022 | East Ridge  | 26 - 21 |  South Lake | 2022 | N/A |
| 2022-10-28 19:00:42October 28, 2022 | CAI Knights | 53 - 0 | Roar Prep & Vocational Academy Lions | 2022 | N/A |
| 2022-10-28 19:00:41October 28, 2022 | Foundation Christian Panthers | 8 - 48 | Oasis Christian Lions | 2022 | N/A |
| 2022-10-28 19:00:40October 28, 2022 | Lake Region Thunder | 39 - 6 | Liberty Chargers | 2022 | N/A |
| 2022-10-28 19:00:40October 28, 2022 | The First Academy Royals | 39 - 0 | A'kelynn's Angels Christian Academy Wildcats | 2022 | N/A |
| 2022-10-28 19:00:39October 28, 2022 | Melbourne  | 49 - 7 |  Viera | 2022 | N/A |
| 2022-10-28 19:00:38October 28, 2022 | Sarasota Christian Blazers | 49 - 17 | Real Life Christian Raptors | 2022 | N/A |
| 2022-10-28 19:00:37October 28, 2022 | Jones  | 47 - 14 |  Horizon | 2022 | N/A |
| 2022-10-28 19:00:37October 28, 2022 | Creekside  | 36 - 7 | Atlantic Coast Stingrays | 2022 | N/A |
| 2022-10-28 19:00:35October 28, 2022 | Eastside  | 28 - 7 | Santa Fe Raiders | 2022 | N/A |
| 2022-10-28 19:00:33October 28, 2022 | Kissimmee Osceola  | 62 - 7 |  Tohopekaliga | 2022 | N/A |
| 2022-10-28 19:00:33October 28, 2022 | St. Francis Catholic Wolves | 6 - 28 | Bronson Eagles | 2022 | N/A |
| 2022-10-28 19:00:32October 28, 2022 | Tocoi Creek  | 35 - 0 | Keystone Heights Indians | 2022 | N/A |
| 2022-10-28 19:00:31October 28, 2022 | Oakleaf  | 20 - 55 |  Bartram Trail | 2022 | N/A |
| 2022-10-28 19:00:29October 28, 2022 | Lake Mary  | 6 - 43 | Sanford Seminole | 2022 | N/A |
| 2022-10-28 19:00:26October 28, 2022 | Umatilla Bulldogs | 14 - 27 | The Villages Charter Buffalo | 2022 | N/A |
| 2022-10-28 19:00:26October 28, 2022 | Foundation Academy Lions | 38 - 36 | West Oaks Academy Flames | 2022 | N/A |
| 2022-10-28 19:00:25October 28, 2022 | Mainland  | 51 - 22 |  Seabreeze | 2022 | N/A |
| 2022-10-28 19:00:25October 28, 2022 | Middleburg  | 35 - 14 |  Orange Park | 2022 | N/A |
| 2022-10-28 19:00:25October 28, 2022 | Blountstown Tigers | 42 - 12 | Port St. Joe Tiger Sharks | 2022 | N/A |
| 2022-10-28 19:00:24October 28, 2022 | Father Lopez Green Wave | 44 - 0 | Halifax Academy Knights | 2022 | N/A |
| 2022-10-28 19:00:24October 28, 2022 | Hope Christian Lions | 20 - 39 | First Coast Christian Knights | 2022 | N/A |
| 2022-10-28 19:00:23October 28, 2022 | Dunnellon  | 6 - 46 | South Sumter Raiders | 2022 | N/A |
| 2022-10-28 19:00:23October 28, 2022 | Old Plank Christian Defenders | 26 - 6 | St. Johns Country Day Spartans | 2022 | N/A |
| 2022-10-28 19:00:22October 28, 2022 | Palatka Panthers | 14 - 35 |  Bradford Tornadoes | 2022 | N/A |
| 2022-10-28 19:00:21October 28, 2022 | Eustis | 49 - 3 |  Mount Dora | 2022 | N/A |
| 2022-10-28 19:00:21October 28, 2022 | Spruce Creek | 21 - 22 |  Hagerty | 2022 | N/A |
| 2022-10-28 19:00:21October 28, 2022 | Trinity Prep Saints | 0 - 62 | Orlando Christian Prep Warriors | 2022 | N/A |
| 2022-10-28 19:00:19October 28, 2022 | Sneads Pirates | 40 - 30 | Holmes County Blue Devils | 2022 | N/A |
| 2022-10-28 19:00:16October 28, 2022 | Winter Park  | 47 - 3 |  Timber Creek | 2022 | N/A |
| 2022-10-28 19:00:16October 28, 2022 | Winter Springs  | 0 - 55 |  Oviedo | 2022 | N/A |
| 2022-10-28 19:00:15October 28, 2022 | FAMU DRS Baby Rattlers | 19:00:157:00 pm | Hamilton County Trojans | 2022 | N/A |
| 2022-10-28 19:00:15October 28, 2022 | Deltona  | 69 - 0 |  Pine Ridge | 2022 | N/A |
| 2022-10-28 19:00:15October 28, 2022 | Oak Ridge Pioneers | 0 - 43 |  Boone | 2022 | N/A |
| 2022-10-28 19:00:15October 28, 2022 | St. Cloud  | 32 - 6 |  Celebration | 2022 | N/A |
| 2022-10-28 19:00:14October 28, 2022 | All Saints Academy Saints | 46 - 12 | Countryside Christian Minutemen | 2022 | N/A |
| 2022-10-28 19:00:13October 28, 2022 | Columbia Tigers | 45 - 0 |  Ridgeview | 2022 | N/A |
| 2022-10-28 19:00:13October 28, 2022 | Master's Academy Patriots | 44 - 12 | Eastland Christian Hurricanes | 2022 | N/A |
| 2022-10-28 19:00:11October 28, 2022 | City of Life Christian Warriors | 6 - 46 |  Merritt Island Christian Cougars | 2022 | N/A |
| 2022-10-28 19:00:10October 28, 2022 | Lake Brantley  | 47 - 24 | Centennial | 2022 | N/A |
| 2022-10-28 19:00:10October 28, 2022 | Orlando Freedom  | 13 - 14 | Orlando Cypress Creek Bears | 2022 | N/A |
| 2022-10-28 19:00:10October 28, 2022 | Hawthorne Hornets  | 19:00:107:00 pm | Dade Christian Crusaders | 2022 | N/A |
| 2022-10-28 19:00:09October 28, 2022 | Winter Haven Blue Devils | 27 - 0 |  Lake Nona | 2022 | N/A |
| 2022-10-28 19:00:06October 28, 2022 | Trenton Tigers | 12 - 26 | Wewahitchka Gators | 2022 | N/A |
| 2022-10-28 19:00:06October 28, 2022 | Bozeman Bucks | 35 - 7 | Liberty County Bulldogs | 2022 | N/A |
| 2022-10-28 19:00:05October 28, 2022 | Lakeside Christian Lions | 44 - 0 | Academy At The Lakes Wildcats | 2022 | N/A |
| 2022-10-28 19:00:04October 28, 2022 | Poinciana Eagles | 42 - 0 | Ambassadors Christian Academy Stallions | 2022 | N/A |
| 2022-10-28 19:00:03October 28, 2022 | P.K. Yonge Blue Wave | 7 - 51 |  Trinity Catholic Celtics | 2022 | N/A |
| 2022-10-28 19:00:02October 28, 2022 | Belleview  | 48 - 0 |  Tavares | 2022 | N/A |
| 2022-10-28 19:00:02October 28, 2022 | Rockledge  | 35 - 0 |  Eau Gallie | 2022 | N/A |
| 2022-10-28 19:00:00October 28, 2022 | Interlachen Rams  | 16 - 0 | Stanton Prep Blue Devils | 2022 | N/A |
| 2022-10-28 19:00:00October 28, 2022 | Paxon Golden Eagles | 52 - 20 | Cocoa Beach Minutemen | 2022 | N/A |
| 2022-10-28 19:00:00October 28, 2022 | Berean Christian Bulldogs | 8 - 14 | First Academy Eagles | 2022 | N/A |
| 2022-10-28 19:00:00October 28, 2022 | Cornerstone Charter Ducks | 43 - 0 | Deltona Trinity Christian Academy Eagles | 2022 | N/A |
| 2022-10-28 19:00:00October 28, 2022 | Eagle's View Academy Warriors | 0 - 36 | Faith Christian Academy Lions | 2022 | N/A |
| 2022-10-28 19:00:00October 28, 2022 | Harvest Community School Warriors | 34 - 32 | Lighthouse PCA Stingrays | 2022 | N/A |
| 2022-10-28 19:00:00October 28, 2022 | Bishop Snyder Cardinals | 13 - 25 | Legacy Charter Eagles | 2022 | N/A |
| 2022-10-28 19:00:00October 28, 2022 | Seven Rivers Christian Warriors | 53 - 20 | Cedar Creek Christian Saints | 2022 | N/A |
| 2022-10-28 19:00:00October 28, 2022 | Out-Of-Door Academy Thunder | 36 - 14 | St. Edward's Pirates | 2022 | N/A |
| 2022-10-28 19:00:00October 28, 2022 | CFCA Eagles | FORFEIT - WIN | Oak Hall Eagles | 2022 | N/A |
| 2022-10-28 19:00:00October 28, 2022 | The Master's Academy Eagles | 13 - 14 | Mount Dora Christian Bulldogs | 2022 | N/A |
| 2022-10-28 19:00:00October 28, 2022 | Westminster Academy Lions | 14 - 50 | Jupiter Christian School Eagles | 2022 | N/A |
| 2022-10-28 19:00:00October 28, 2022 | Lake Highland Prep Highlanders | 52 - 16 | Fort Myers Canterbury Cougars | 2022 | N/A |
| 2022-10-28 16:00:03October 28, 2022 | Hernando Christian Lions | 66 - 38 | Cornerstone Academy Cougars | 2022 | N/A |
| 2022-10-27 19:00:57October 27, 2022 | Buchholz  | 49 - 35 |  Fleming Island | 2022 | N/A |
| 2022-10-27 19:00:39October 27, 2022 | New Smyrna Beach | 28 - 35 | DeLand | 2022 | N/A |
| 2022-10-27 19:00:39October 27, 2022 | East River Falcons | 10 - 0 |  Lake Howell | 2022 | N/A |
| 2022-10-27 19:00:35October 27, 2022 | Apopka | 23 - 12 |  Evans | 2022 | N/A |
| 2022-10-27 19:00:34October 27, 2022 | Dr. Phillips  | 28 - 25 | Ocoee | 2022 | N/A |
| 2022-10-27 19:00:33October 27, 2022 | Lake Weir Hurricanes  | 30 - 28 | Crescent City Raiders | 2022 | N/A |
| 2022-10-27 19:00:31October 27, 2022 | West Orange | 37 - 14 |  Olympia | 2022 | N/A |
| 2022-10-27 19:00:30October 27, 2022 | Sebastian River Sharks | 28 - 20 | American Collegiate Academy Rough Riders | 2022 | N/A |
| 2022-10-27 19:00:26October 27, 2022 | Newberry Panthers | 30 - 0 | Dixie County Bears | 2022 | N/A |
| 2022-10-27 19:00:20October 27, 2022 | Palm Beach Christian Saints | 32 - 7 | Glades Day Gators | 2022 | N/A |
| 2022-10-27 19:00:15October 27, 2022 | IMG Academy Varsity Blue Ascenders | 16 - 35 | Nature Coast Tech Sharks | 2022 | N/A |
| 2022-10-27 19:00:08October 27, 2022 | Lake Buena Vista Vipers | 12 - 49 |  Bishop Moore | 2022 | N/A |
| 2022-10-27 19:00:02October 27, 2022 | St. Joseph Academy Flashes | 18 - 55 |  Beachside | 2022 | N/A |
| 2022-10-27 19:00:00October 27, 2022 | Bell Creek Academy Panthers | 14 - 42 | Oasis Sharks | 2022 | N/A |
| 2022-10-27 19:00:00October 27, 2022 | Gateway Charter Griffins | 33 - 14 | Bradenton Christian Panthers | 2022 | N/A |
| 2022-10-27 19:00:00October 27, 2022 | Saint Stephen's Episcopal Falcons | 42 - 27 | Santa Fe Catholic Hawks | 2022 | N/A |
| 2022-10-27 16:00:56October 27, 2022 | Duval Charter School Panthers | 26 - 16 | FSDB Dragons | 2022 | N/A |
| 2022-10-27 16:00:00October 27, 2022 | Boca Raton Christian Blazers | 21 - 36 | Tradition Prep Pirates | 2022 | N/A |
